Metaplastic Carcinoma of the Breast Is More Aggressive Than Triple-negative Breast Cancer: A Study From a Single Institution and Review of Literature

Clinical Breast Cancer
Dima El ZeinThaer Khoury

Abstract

We aimed to describe our experience with metaplastic breast carcinoma (MBC), evaluate its clinical outcome compared with triple-negative breast cancer (TNBC), and provide a through and comprehensive review of the literature to date. We reviewed MBC cases (n = 46) from our institution. The following variables were recorded: tumor histologic subtype, Nottingham grade, tumor size, lymph node status, Tumor, Node, Metastases stage, biomarkers profile, patient's age and race, therapy modality (chemotherapy and radiation), and survival (disease-free survival [DFS] and overall survival [OS]). The clinical and pathological data for TNBC (n = 508) cases were extracted from the breast cancer database. To compare the survival between MBC and TNBC, a subgroup of MBC cases (n = 40) were matched with TNBC cases (n = 40) on the basis of known prognostic confounders. There were 17 of 46 (37%) cases with mesenchymal differentiation, 12 (26.1%) squamous cell carcinoma, 14 (30.4%) spindle cell carcinoma, and 3 (6.5%) mixed type. MBC presented at a more advanced stage than TNBC (P = .014) and was more likely to recur (34% vs. 15.5%; P = .004). More MBC patients died from disease than TNBC (29% vs. 16%; P = .05). In the multivariate analysis, MBC ha...Continue Reading

Citations

Oct 24, 2018·The Journal of Pathology·Amy Ellen McCart ReedSunil R Lakhani
Mar 14, 2019·Cancer Medicine·William R KennedyImran Zoberi
Aug 20, 2020·Breast Cancer Research : BCR·Xue ChaoJingping Yun
Jun 28, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Gregor Krings, Yunn-Yi Chen
Nov 29, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Emily R McMullenCelina G Kleer
Jan 4, 2021·Annals of Surgical Oncology·Audree B TadrosGeorge Plitas
Feb 5, 2021·Future Oncology·Gennaro Gadaleta-CaldarolaStefania Infusino
Mar 6, 2021·Breast Cancer : Targets and Therapy·Amy E McCart ReedSunil R Lakhani
Mar 8, 2021·Translational Oncology·Jin HuTao Huang
Aug 29, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Min HanDavid J Dabbs
Jul 24, 2021·NPJ Breast Cancer·Willard WongHannah Y Wen
Jul 25, 2021·International Journal of Molecular Sciences·Silvia González-MartínezJosé Palacios
Jun 12, 2021·The American Journal of Surgical Pathology·Anne GrabenstetterHannah Y Wen
Nov 12, 2021·The Journal of Medical Investigation : JMI·Yoshimi BandoHisanor Uehara

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