Metaplasticity contributes to memory formation in the hippocampus.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Ana Paula CrestaniBrian J Wiltgen

Abstract

Prior learning can modify the plasticity mechanisms that are used to encode new information. For example, NMDA receptor (NMDAR) activation is typically required for new spatial and contextual learning in the hippocampus. However, once animals have acquired this information, they can learn new tasks even if NMDARs are blocked. This finding suggests that behavioral training alters cellular plasticity mechanisms such that NMDARs are not required for subsequent learning. The mechanisms that mediate this change are currently unknown. To address this issue, we tested the idea that changes in intrinsic excitability (induced by learning) facilitate the encoding of new memories via metabotropic glutamate receptor (mGluR) activation. Consistent with this hypothesis, hippocampal neurons exhibited increases in intrinsic excitability after learning that lasted for several days. This increase was selective and only observed in neurons that were activated by the learning event. When animals were trained on a new task during this period, excitable neurons were reactivated and memory formation required the activation of mGluRs instead of NMDARs. These data suggest that increases in intrinsic excitability may serve as a metaplastic mechanism for...Continue Reading

References

Aug 29, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R G MorrisS P Butcher
May 14, 1999·Current Opinion in Neurobiology·Y Elgersma, A J Silva
Jun 26, 2003·The European Journal of Neuroscience·Drorit Saar, Edi Barkai
Aug 23, 2003·Neurobiology of Learning and Memory·Matthew J Sanders, Michael S Fanselow
Nov 2, 2005·Nature Reviews. Neuroscience·Roger A Nicoll, Dietmar Schmitz
Feb 14, 2007·Neuron·Benjamin D PhilpotMark F Bear
Apr 7, 2007·Science·Dorothy TseRichard G M Morris
Jan 9, 2010·Frontiers in Molecular Neuroscience·Leon Reijmers, Mark Mayford
Oct 19, 2010·Frontiers in Behavioral Neuroscience·Stephan G AnagnostarasGerald M Herrera
Oct 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Szu-Han WangRichard G M Morris
Jun 2, 2011·Frontiers in Behavioral Neuroscience·Kaycie Kuss TaylerBrian J Wiltgen
Jul 9, 2011·Science·Dorothy TseRichard G M Morris
Nov 17, 2011·Learning & Memory·Brian J WiltgenBrynne Levy
Dec 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Won Chan OhKaren Zito
Jul 28, 2013·Science·Steve RamirezSusumu Tonegawa
Apr 14, 2016·Hippocampus·Yuki NakazawaBrian J Wiltgen
Dec 3, 2017·Neurobiology of Learning and Memory·Naveen Chandra, Edi Barkai
Mar 5, 2018·Neurobiology of Learning and Memory·Ana Paula CrestaniJorge Alberto Quillfeldt
Apr 28, 2018·Science·Jun-Hyeok ChoiBong-Kiun Kaang

❮ Previous
Next ❯

Citations

Mar 16, 2019·Nature Reviews. Neuroscience·Andrew P YonelinasBrian J Wiltgen
Dec 1, 2020·Frontiers in Cellular Neuroscience·Charlotte PietteLaurent Venance
Mar 27, 2021·Frontiers in Behavioral Neuroscience·Jalina GrahamBrian J Wiltgen
Apr 4, 2021·Brain Sciences·Yosef Avchalumov, Chitra D Mandyam
Jul 10, 2021·Neuron·André F de SousaAlcino J Silva

❮ Previous
Next ❯

Software Mentioned

ImageJ
pClamp

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.