Metaplasticity: tuning synapses and networks for plasticity

Nature Reviews. Neuroscience
Wickliffe C Abraham

Abstract

Synaptic plasticity is a key component of the learning machinery in the brain. It is vital that such plasticity be tightly regulated so that it occurs to the proper extent at the proper time. Activity-dependent mechanisms that have been collectively termed metaplasticity have evolved to help implement these essential computational constraints. Various intercellular signalling molecules can trigger lasting changes in the ability of synapses to express plasticity; their mechanisms of action are reviewed here, along with a consideration of how metaplasticity might affect learning and clinical conditions.

References

Nov 24, 1978·Brain Research·B L McNaughtonG V Goddard
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·X D Yang, D S Faber
May 1, 1991·Brain Research. Brain Research Reviews·D L AlkonL K Gorman
Oct 23, 1989·Neuroscience Letters·E J CoanG L Collingridge
Jul 3, 1987·Science·M F BearF F Ebner
Oct 29, 1982·Science·E R Kandel, J H Schwartz
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·P K Stanton
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·J I Gold, M F Bear
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·L BenuskováF F Ebner
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·D S Kerr, W C Abraham
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·J J KimR F Thompson
Apr 1, 1996·Trends in Neurosciences·W C Abraham, M F Bear
Dec 1, 1995·Current Biology : CB·K DeisserothR W Tsien
Aug 1, 1996·Journal of Neurophysiology·A S Cohen, W C Abraham
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Feb 6, 1997·Nature·U Frey, R G Morris
Jul 1, 1997·Progress in Neurobiology·W C Abraham, W P Tate
Jan 9, 1999·Trends in Neurosciences·J J Kim, K S Yoon
Oct 9, 1999·Journal of Neurophysiology·H Wang, J J Wagner

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Citations

Oct 4, 2011·Experimental Brain Research·Sebastian H Doeltgen, Michael C Ridding
Nov 30, 2012·Experimental Brain Research·M A EdwardsonE E Fetz
Sep 26, 2013·European Archives of Psychiatry and Clinical Neuroscience·Alkomiet HasanZafiris J Daskalakis
Feb 12, 2013·Cell and Tissue Research·Jean-Bernard Dietrich
Apr 24, 2010·Journal of Molecular Neuroscience : MN·Kai YangJohn F Macdonald
Apr 18, 2013·Artificial Intelligence in Medicine·Alexis Marcano-CedeñoEnrique J Gómez
Jun 19, 2013·Neurochemistry International·Ming-Lei GuoJohn Q Wang
Jan 13, 2009·Nature Neuroscience·Khaled MoussawiPeter W Kalivas
Apr 9, 2013·Nature Neuroscience·Wataru InoueJaideep S Bains
Jul 16, 2013·Nature Neuroscience·David L HuntPablo E Castillo
Dec 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ming Teng KohMichela Gallagher
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jeffrey BurgdorfJoseph R Moskal
Mar 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kathleen K A ChoMark F Bear
Jan 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sreedharan Sajikumar, Martin Korte
May 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andreas VlachosThomas Deller
May 19, 2012·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Iris R BellGary E Schwartz
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sarah R HulmeWickliffe C Abraham
Jan 17, 2013·Learning & Memory·Iva B ZovkicJ David Sweatt
Jun 26, 2009·Learning & Memory·Jerry W Rudy, Patricia Matus-Amat
Nov 3, 2010·Learning & Memory·Brittany M ThompsonSteven F Maier
Jun 23, 2009·Science·Martin Korte
Apr 30, 2009·Science Signaling·Marcelo P CobaSeth G N Grant
Jul 7, 2009·Annual Review of Physiology·Boris D Heifets, Pablo E Castillo
May 12, 2010·Journal of Neurophysiology·Rishikesh Narayanan, Sumantra Chattarji
Mar 9, 2013·Journal of Cognitive Neuroscience·Benjamin BeckerRené Hurlemann
Feb 10, 2010·Neural Computation·Michael PfeifferWolfgang Maass
Aug 24, 2013·Molecular Brain·Richard C GerkinGuo-Qiang Bi
Jul 9, 2011·PLoS Computational Biology·Johannes FriedrichWalter Senn
Nov 19, 2013·PLoS Computational Biology·Friedemann ZenkeWulfram Gerstner

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