PMID: 11911714Mar 26, 2002Paper

METAPRINT: a metabolic fingerprint. Application to cassette design for high-throughput ADME screening

Journal of Chemical Information and Computer Sciences
György M Keseruu, László Molnar

Abstract

METAPRINT, a metabolic fingerprint, has been developed by predicting metabolic pathways and corresponding potential metabolites. Calculated drug-likeness parameters (log P and MW) have been incorporated into METAPRINT to allow the encoding of metabolic diversity within a chemical library. The application of METAPRINT in the design of cassette dosing experiments is demonstrated using a library of alpha-1a antagonists synthesized at Glaxo Wellcome. Results obtained by Ward's clustering algorithm suggest that METAPRINTs are able to discriminate between low- and high-clearance compounds. Cassette design was performed by maximizing the intracassette Euclidean distances between compounds in METAPRINT space, using simulated annealing. Calculated distances in METAPRINT space were in accordance with experimental data.

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Citations

Aug 23, 2006·Expert Opinion on Drug Metabolism & Toxicology·Sean EkinsTatiana Nikolskaya
Oct 5, 2007·Journal of Pharmaceutical Sciences·Kan HeScott J Grossman
Jul 29, 2004·Drug Discovery Today·Prasarn Manitpisitkul, Ronald E White
Jun 30, 2016·Journal of Computational Chemistry·Iwona E Weidlich, Igor V Filippov

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