Metastability in Senescence

Trends in Cognitive Sciences
Shruti NaikDipanjan Roy

Abstract

The brain during healthy aging exhibits gradual deterioration of structure but maintains a high level of cognitive ability. These structural changes are often accompanied by reorganization of functional brain networks. Existing neurocognitive theories of aging have argued that such changes are either beneficial or detrimental. Despite numerous empirical investigations, the field lacks a coherent account of the dynamic processes that occur over our lifespan. Taking advantage of the recent developments in whole-brain computational modeling approaches, we hypothesize that the continuous process of aging can be explained by the concepts of metastability - a theoretical framework that gives a systematic account of the variability of the brain. This hypothesis can bridge the gap between existing theories and the empirical findings on age-related changes.

Citations

Jun 3, 2018·Chaos·Rupak Mukherjee, Abhijit Sen
Sep 27, 2018·Frontiers in Computational Neuroscience·Tommaso GiliGianfranco Spalletta
Jan 31, 2020·Frontiers in Aging Neuroscience·Duan LiPhillip E Vlisides
Jan 23, 2018·Frontiers in Aging Neuroscience·Alexandru D IordanPatricia A Reuter-Lorenz
Jan 29, 2019·Frontiers in Systems Neuroscience·Oleksandr V PopovychSimon B Eickhoff
Feb 4, 2021·Human Brain Mapping·Alexandru D IordanPatricia A Reuter-Lorenz
Jan 8, 2021·Alzheimer's Research & Therapy·Adeline Su Lyn NgJuan Helen Zhou
Feb 5, 2021·Nature Reviews. Neuroscience·Lucina Q Uddin
Jul 1, 2021·Network Neuroscience·Dipanjan Roy, Lucina Q Uddin
Jul 28, 2021·Human Brain Mapping·William SnyderJason S Nomi
Apr 15, 2020·NeuroImage·Bikash SahooDipanjan Roy

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