PMID: 8948480Nov 13, 1996Paper

Metastable rippled gel phase in saturated phosphatidylcholines: calorimetric and densitometric characterization

Biochimica Et Biophysica Acta
R D KoynovaB Tenchov

Abstract

A long-living metastable rippled phase P beta' mst has been earlier reported to form in aqueous dispersions of dipalmitoylphosphatidylcholine (DPPC) upon cooling from the lamellar liquid crystalline phase L alpha (Tenchov et al. (1989) Biophys. J. 56, 757-768). Here we demonstrate that similar metastable phases form also in distearoylphosphatidylcholine (DSPC) and dihexadecylphosphatidylcholine (DHPC) but not in dimyristoylphosphatidylcholine (DMPC). The thermodynamic parameters of P beta' mst in DPPC, DSPC and DHPC have been characterized in detail by means of differential scanning calorimetry and scanning densitometry. It is shown that the P beta' mst phase in these three lipids has higher specific heat capacity by 0.1-0.4 kcal K-1 mol-1 and higher specific volume by 1-2 microliters/g than the equilibrium P beta' phase formed upon heating from the L beta' phase. The P beta' mst-->L alpha transition in these three lipids takes place at 0.06-0.14 degree C lower temperature than the P beta'-->L alpha transition. Its enthalpy is lower by 5-11% and the apparent maximum specific heat Cp max is lower by 11-14%. The P beta' mst phase is a long-living phase-it does not relax into the equilibrium P beta' for at least several hours. The...Continue Reading

References

Jun 1, 1987·Chemistry and Physics of Lipids·P LaggnerA Schuster
Jan 1, 1986·Methods in Enzymology·P L Privalov, S A Potekhin
May 21, 1982·Biochimica Et Biophysica Acta·D A Wilkinson, J F Nagle
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K KokB Carritt

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Citations

May 25, 2013·Pharmaceutical Research·Cláudia NunesSalette Reis
Jul 17, 1998·Biochimica Et Biophysica Acta·R Koynova, M Caffrey
Feb 27, 2003·Journal of Liposome Research·Anthony KennedyThomas J Reid
Jan 10, 2012·Colloids and Surfaces. B, Biointerfaces·Nobutake TamaiShoji Kaneshina
Aug 31, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Brigitte StarkRuth Prassl
Jan 2, 2007·Chemistry and Physics of Lipids·Daniela UhríkováPavol Balgavý
May 10, 2005·Biophysical Journal·A Charrier, F Thibaudau
Apr 2, 2019·Chemical & Pharmaceutical Bulletin·Hitoshi MatsukiNobutake Tamai
Apr 14, 2021·Journal of Medicinal Chemistry·Daniela Lopes-de-CamposSalette Reis

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