Metastasis-Free Interval Is Closely Related to Tumor Characteristics and Has Prognostic Value in Breast Cancer Patients with Distant Relapse

Journal of breast cancer
Hee Jun KimJoon Jeong

Abstract

We investigated the relationships between metastasis-free interval (MFI) and tumor characteristics, and assessed the prognostic value of MFI for survival after metastasis in patients with metastatic breast cancer. Furthermore, we compared MFI among the subtypes. We identified 335 patients with postoperative tumor recurrence at distant site(s). All patients underwent curative resection and had a MFI of at least 6 months. MFI was categorized as short (<2 years), intermediate (≥2 years and <5 years), or long (≥5 years). Overall survival after metastasis (OSM) was estimated. Patients with a shorter MFI were younger, more likely to have initial metastasis to visceral organs, and had a larger tumor with a higher stage and grade as well as a higher rate of nodal involvement at initial diagnosis. Among 136 patients with known disease subtypes, shorter MFI was associated with the triple-negative subtype while longer MFI was associated with the hormone receptor-positive/human epidermal growth factor receptor 2 negative subtype. Mortality after metastasis declined sharply with increasing MFI up to approximately 2 years, and continued gradually declining between 2 and 5 years. An MFI longer than 5 years did not add any survival benefit. MF...Continue Reading

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Citations

Jun 19, 2016·The Breast : Official Journal of the European Society of Mastology·Jacques Bernier, Philip M P Poortmans
Jan 20, 2017·Virchows Archiv : an International Journal of Pathology·István Artúr MolnárAnna-Mária Tőkés
Apr 25, 2018·The Breast Journal·Kelsey E LarsonStephanie A Valente
Oct 18, 2018·Breast Cancer Research and Treatment·Victoria SopikSteven A Narod
Aug 6, 2021·JCO Clinical Cancer Informatics·Carlos H BarcenasGabriel N Hortobagyi
Nov 1, 2018·Biomedicine Hub·Elisa M SchunkertKurt Zänker

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Methods Mentioned

BETA
biopsies

Software Mentioned

R
SPSS

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