Metastasis of cutaneous squamous cell carcinoma in organ transplant recipients and the immunocompetent population: is there a difference? a systematic review and meta-analysis

Journal of the European Academy of Dermatology and Venereology : JEADV
R E GendersE I Plasmeijer

Abstract

Organ transplant recipients (OTR) have a higher risk of developing cutaneous squamous cell carcinoma (cSCC) compared to the immunocompetent population. Immunosuppression is often stated as a risk factor for metastasis. However, evidence for this is scarce. To investigate the cSCC metastasis risk in OTR and the immunocompetent population by systematically reviewing the literature. A systematic review of the literature was performed up to January 2018 using: Medline; Embase; Web of Science and ISI Science Citation Index. Studies assessing cSCC metastasis risk in ORT or immunocompetent cohorts were considered. A pooled risk estimate for metastasis was calculated for the immunocompetent population and OTR separately. The pooled metastasis risk estimate for OTR was, respectively, 7.3% (95% CI 6.2-8.4) for cSCC on total body, and 11.0% (95% CI 7.7-14.8) for cSCC of the head neck area. For the immunocompetent population reported risk estimate analysis showed a pooled metastatic risk of 3.1% (95% CI 2.8-3.4) in total body cSCC and of 8.5% (95% CI 7.3-9.8) in cSCC of the head and neck area. Pooled risk estimate per single cSCC in OTR was 1.3% (95% CI 1.0-1.7) in total body cSCC and 4.0% (95% CI 2.7-5.5) in cSCC of the head and neck area...Continue Reading

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Citations

Aug 17, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Nick MarsidiRoel E Genders
Apr 29, 2020·Journal of the American Academy of Dermatology·Ashley WysongSarah T Arron
Aug 28, 2021·Cancers·Thomas MeyerEggert Stockfleth
Oct 1, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·C DessiniotiA J Stratigos
Oct 16, 2021·Journal of the American Academy of Dermatology·Selin TokezLoes M Hollestein
Dec 3, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·E de JongJ N Bouwes Bavinck
Dec 3, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·R Kaufmann

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