Metastasis of renal cell carcinoma to the parathyroid gland 12 years after radical nephrectomy

Journal of Surgical Case Reports
Débora MeloFátima Caratão

Abstract

Renal cell carcinoma (RCC) accounts for 2-3% of all malignant tumors in adults. RCC is well-known for its propensity to metastasize to unusual sites, and late metastasis, even after several years, is common. Involvement of the parathyroid gland has only four reported cases in literature. A 62-year-old Caucasian man was referred to our department due to an enlarging cervical mass. The patient's relevant past medical history included a left nephrectomy for RCC 12 years ago. After right thyroid lobectomy and isthmectomy, histopathology revealed an intrathyroidal nodule corresponding to the parathyroid gland with metastatic RCC. Approximately one-third of RCC subjects with apparently localized disease will develop metastasis, even several years after nephrectomy. The literature is sparse regarding the most appropriate follow-up approach for these patients. We describe a rare case of nodular goiter of the thyroid gland concurrent with metastatic RCC to an intrathyroidal parathyroid gland, without disseminated systemic metastasis.

References

Mar 4, 2008·Cancer Treatment Reviews·Kiran GuptaClaudie Charbonneau
Apr 1, 2011·The American Journal of Surgical Pathology·Ashley Cimino-MathewsGeorge J Netto
Sep 6, 2011·Journal of Medical Case Reports·Petros SountoulidesLuca Cindolo
Dec 10, 2014·The Journal of Clinical Endocrinology and Metabolism·Alexander ShifrinJohn Davis
Sep 7, 2017·Head and Neck Pathology·Justin L BauerLester D R Thompson

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