PMID: 9550215Apr 29, 1998Paper

Metastasis of Theileria annulata macroschizont-infected cells in scid mice is mediated by matrix metalloproteinases

Parasitology
R P SomervilleF R Hall

Abstract

Theileria annulata (Ta)-infected leucocytes are able to disseminate in scid mice. The dose of virulent parasites of the Ta-Ode line required to achieve quantifiable dissemination was found to be 2 x 10(6) cells given i.p. Dissemination was higher on day 11 post-inoculation than on day 18. The attenuated Ta-Ode cells were found to disseminate very poorly compared to their virulent progenitors, which correlates with a marked reduction in matrix metalloproteinase (MMP) expression. A daily i.p. injection of mice with BB94, a synthetic inhibitor of MMPs, almost completely ablated dissemination compared to controls. This provides strong evidence that metastasis of Theileria annulata macroschizont-infected host cells is mediated by host MMPs induced by the parasite. This has important implications for explaining a number of pathological features of tropical theileriosis in cattle.

Citations

Dec 24, 2011·Cancer Research·Alicia M Cock-RadaJonathan B Weitzman
Oct 30, 1999·Tropical Medicine & International Health : TM & IH·R HallR Adamson
Jul 29, 2011·Current Opinion in Microbiology·Martin Baumgartner
Nov 5, 1999·Annual Review of Microbiology·D Dobbelaere, V Heussler
Nov 7, 2014·PLoS Neglected Tropical Diseases·Nadia EchebliGordon Langsley
Jan 15, 2019·Free Radical Biology & Medicine·Malak HaidarGordon Langsley

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