Metastasis Stemming from Circulating Tumor Cell Clusters

Trends in Cell Biology
Min Yu

Abstract

Circulating tumor cell (CTC) clusters have an enhanced capacity to initiate metastases, compared with single cells, but it is unclear how they gain such advantage. A recent study by Gkountela etal. (Cell 2019;176:98-112) links the physical state of clusters with increased accessibility of stem cell-related transcription factors, providing novel insights into the epigenetic regulation of 'stemness' in CTC clusters.

Citations

Aug 30, 2019·Cells·Elisabetta Rossi, Francesco Fabbri
Jul 2, 2020·International Journal of Molecular Sciences·Stefania CoccoMichelino De Laurentiis
Apr 27, 2019·Frontiers in Oncology·Matteo SantoniRodolfo Montironi
May 12, 2020·Frontiers in Molecular Biosciences·Deguang KongHeide L Ford
Feb 14, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tao YuXiaoxiang Guan
Aug 26, 2021·Molecular Biology of the Cell·Alexander J DevannyLaura J Kaufman

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