PMID: 9180929May 1, 1997Paper

Metastatic ability of MXT mouse mammary subpopulations correlates with clonal expression and/or membrane-association of gelatinase A

Molecular Carcinogenesis
A LlorensA Fabra

Abstract

We have developed a novel murine mammary tumor system with variants representing different stages of tumor progression. The MXT-s parental cell line was established from a urethane-induced and hormone-sensitive mammary tumor. MXT-s parental cells are highly tumorigenic but poorly metastatic. MXT clones and variants were selected by either in vitro or in vivo procedures, and they differ in metastatic ability and 17 beta-estradiol dependency for tumor growth. The MXT-c1.1 and MXT-B2 cell lines produced lung metastasis after intravenous injection into 100% of syngenic mice, but only MXT-c1.1 cells were highly metastatic from intramammary tumors. The fingerprints obtained by arbitrarily primed-polymerase chain reaction demonstrated that the metastatic variants and clones had a common genetic background and resulted from clonal selection from the parental cell line. We studied whether the matrix metalloproteinase (MMP) profile is correlated with tumor progression and metastatic ability in the MXT tumor system. Gelatinases A and B were assayed in the cells, both by enzyme activity and mRNA expression. Gelatinase A was expressed in MXT-c1.1 cells, whereas MXT-B2 cells did not express either MMP. In contrast, the mammary fat pad tumors...Continue Reading

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Citations

Oct 12, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S M Ellerbroek, M S Stack
May 12, 2001·Pathology Oncology Research : POR·A John, G Tuszynski
Jul 28, 2007·Reviews in Endocrine & Metabolic Disorders·Ann E VernonLewis A Chodosh
Oct 27, 1999·European Journal of Cell Biology·M Guerrero-EsteoC Bernabéu
Dec 31, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Mafalda VideiraAngels Fabra
Dec 20, 2000·Experimental Cell Research·A PuyraimondS Menashi

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