PMID: 2106257Feb 1, 1990Paper

Metastatic adenocarcinomas of unknown primary site. Prognostic variables and treatment results

American Journal of Clinical Oncology
S A KambhuR Rosenbluth

Abstract

As part of a Phase II chemotherapy trial using mitomycin-C, adriamycin, and vindesine, 57 patients with adenocarcinoma of unknown primary site were assessed for prognostic variables predictive of response and survival. They were also evaluated for response and toxicity, usefulness of screening techniques, and eventual definition of primary site and pattern of progression. Only gender predicted response, with women being more likely to respond than men. Visceral metastases below the diaphragm, or the presence of liver metastases, predicted poor survival. Responding patients were highly likely to relapse first at sites of initial disease. Hemolytic-uremic syndrome was the most severe toxicity; other side effects were moderate. The response rate was 30% (three complete responders), which is similar to other current regimens. This study suggests that patients with better prognosis characteristics of single site of disease and without intraabdominal tumor may benefit from a policy of expectant observation after local control has been established. Patients with multiple sites of disease and/or intraabdominal tumor are appropriate candidates for investigational chemotherapy.

Citations

Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·J E Ultmann
Jul 27, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J Ponce LorenzoJ Montalar Salcedo
Jan 24, 2014·South Asian Journal of Cancer·Kanaram ChoudharyAkhil Nambyar
Mar 7, 2006·Gastroentérologie Clinique Et Biologique·Damien PouesselMarc Ychou
Jan 9, 2013·Veterinary and Comparative Oncology·F RossiL Marconato
Apr 1, 1996·Hematology/oncology Clinics of North America·M RyttingN Jaffe
Apr 1, 1997·Japanese Journal of Clinical Oncology·D C WuJ Whang-Peng
Dec 19, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stéphane CulineUNKNOWN French Study Group on Carcinomas of Unknown Primary
Dec 1, 1994·Cancer·C CanpolatN Jaffe
Jun 15, 2007·Acta Oncologica·Nicholas Pavlidis
Aug 26, 1998·Renal Failure·R M Viero, V A Soares
Jan 3, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tarik M Elsheikh, Jan F Silverman
Oct 1, 1991·Pharmacology & Therapeutics·E K Rowinsky, R C Donehower
Apr 1, 1994·Cancer Treatment Reviews·G Daugaard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.