Metastatic bladder cancer: advances in treatment

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
W M StadlerF A Dorr

Abstract

At present, a combination of cisplatin, methotrexate, vinblastine and doxorubicin is the most widely used chemotherapy for metastatic bladder cancer. However, long-term follow-up shows that this combination may have little effect on survival. In addition, this regimen is toxic. New agents are needed which combine efficacy with good safety profiles. Agents which have been investigated include gallium nitrate, interferon-alpha and paclitaxel both as single agents and in combination with established cytotoxic drugs. A number of studies have been conducted in bladder cancer with the novel nucleoside analogue, gemcitabine. Response rates of up to 33% have been recorded in two phase II studies. Gemcitabine was well tolerated in both studies with few of the side-effects normally associated with cytotoxic drugs. A third study is ongoing.

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Citations

Mar 25, 2011·International Journal of Clinical Oncology·Hiroshi TsurutaTomonori Habuchi
Jan 25, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Terence T SioUzair B Chaudhary
Apr 20, 2012·The Cochrane Database of Systematic Reviews·May N TsaoArjun Sahgal
Jan 25, 2018·The Cochrane Database of Systematic Reviews·May N TsaoEdward Chow
Jul 13, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A SantoroV Diehl

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