Metastatic bronchioloalveolar carcinoma presenting as a solitary thyroid nodule: report of a case with fine-needle aspiration cytopathology

Diagnostic Cytopathology
Anil V ParwaniS Z Ali

Abstract

Although cancers metastatic to the thyroid are frequently mentioned in autopsy studies, such a finding is quite rare in routine clinical practice. Metastatic non-small-cell carcinomas to the thyroid may present a diagnostic dilemma, particularly when they share morphological similarities with primary thyroid tumors. Herein, we report a case of metastatic bronchioloalveolar carcinoma that presented as an isolated left thyroid nodule in a 68-year-old woman. The aspirates were cellular and showed numerous papillary-like tissue fragments, elongated nuclei with prominent nuclear grooves, frequent mitoses, and psammoma bodies. The latter features raised the possibility of papillary thyroid carcinoma. However, also seen were three-dimensional tumor nests and acinar-forming fragments. Immunostains (positive for cytokeratin-7 and carcinoembryonic antigen and negative for cytokeratin-20 and thyroglobulin) confirmed the metastatic nature of the carcinoma. In a patient with known primary neoplasm, the differential diagnosis of a thyroid nodule should always include a metastatic lesion along with primary neoplasia.

References

Mar 1, 1991·The Annals of Thoracic Surgery·R C DalyT V Colby
Jan 1, 1987·The American Journal of the Medical Sciences·N B Watts
Dec 1, 1984·Mayo Clinic Proceedings·H K Ivy
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·B R HaugenE C Ridgway
Feb 1, 1997·Cancer·M K NakhjavaniJ A van Heerden
Jan 8, 1999·World Journal of Surgery·H ChenR Udelsman
Feb 14, 2003·Lancet·Steven I Sherman
Jun 10, 1961·British Medical Journal·J WILLIS

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