Metastatic Colonization: Escaping Immune Surveillance

Cancers
Julien Schaller, Judith Agudo

Abstract

Cancer immunotherapy has shifted the paradigm in cancer therapy by revitalizing immune responses against tumor cells. Specifically, in primary tumors cancer cells evolve in an immunosuppressive microenvironment, which protects them from immune attack. However, during tumor progression, some cancer cells leave the protective tumor mass, disseminating and seeding secondary organs. These initial disseminated tumor cells (DTCs) should potentially be susceptible to recognition by the immune system in the new host tissues. Although Natural Killer or T cells eliminate some of these DTCs, a fraction escape anti-tumor immunity and survive, thus giving rise to metastatic colonization. How DTCs interact with immune cells and the underpinnings that regulate imperfect immune responses during tumor dissemination remain poorly understood. Uncovering such mechanisms of immune evasion may contribute to the development of immunotherapy specifically targeting DTCs. Here we review current knowledge about systemic and site-specific immune-cancer crosstalk in the early steps of metastasis formation. Moreover, we highlight how conventional cancer therapies can shape the pre-metastatic niche enabling immune escape of newly arrived DTCs.

References

Mar 10, 2001·International Journal of Cancer. Journal International Du Cancer·J KamarashevR Dummer
Jul 21, 2004·Cancer Cell·Minna AllinenKornelia Polyak
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sung-Joo ParkToshio Hirano
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jack D BuiRobert D Schreiber
Dec 26, 2008·The New England Journal of Medicine·Anne C Chiang, Joan Massagué
Jan 6, 2009·Immunological Reviews·Olivier JoffreCaetano Reis e Sousa
Apr 29, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rikiya NakamuraMasaru Miyazaki
May 27, 2010·The Journal of Clinical Investigation·Jo EylesJean-Pierre Abastado
Jul 14, 2010·Nature Medicine·Donna L HerberDmitry I Gabrilovich
Aug 5, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Liufu DengShengdian Wang
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Huiping LiuMichael F Clarke
Nov 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marcin KowanetzNapoleone Ferrara
Dec 15, 2010·Cell Biology International·Dahui SunYan Zhang
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 26, 2011·Science·Christine L Chaffer, Robert A Weinberg
Jun 10, 2011·Nature·Bin-Zhi QianJeffrey W Pollard
Nov 9, 2011·Cancer Immunology, Immunotherapy : CII·Yan LiuHideho Okada
Oct 9, 2012·The Journal of Clinical Investigation·Julie HelftMiriam Merad
Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Joanna BaginskaBassam Janji
Nov 10, 2013·Nature Medicine·Daniela F Quail, Johanna A Joyce
Mar 13, 2014·Cell Stem Cell·Thordur OskarssonJoan Massagué
Jul 23, 2014·Oncoimmunology·Aroa Baragaño RanerosCarlos López-Larrea
Apr 11, 2015·Cancer Cell·Suzanne L TopalianDrew M Pardoll
Apr 26, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sharad K SharmaMaciej M Markiewski
Jun 14, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandra ZingoniAngela Santoni
Oct 24, 2015·Science·Richard N HannaCatherine C Hedrick
Nov 3, 2015·Nature·Ayuko HoshinoDavid Lyden

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Citations

Jan 14, 2021·International Journal of Molecular Sciences·Han Yeoung LeeJong Kook Park
Jul 10, 2021·Cellular and Molecular Life Sciences : CMLS·Lionel GillotAgnès Noël

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