Metastatic Cutaneous Duodenal Gastrointestinal Stromal Tumor: A Possible Clue to Multiple Metastases

Annals of Dermatology
Young Jae KimMi Woo Lee

Abstract

We report a case of a 69-year-old man with metastatic cutaneous duodenal gastrointestinal stromal tumor, which led to find multiple metastases on orbital muscle and scalp. The patient presented with a rapidly growing chest nodule with mild tenderness. He underwent surgical resection for duodenal gastrointestinal stromal tumor and had been treated with imatinib for three years. Histopathological examination of the chest nodule was consistent with gastrointestinal stromal tumor. A brain magnetic resonance imaging of follow work-up revealed multiple metastases at the left superior rectus muscle and occipital scalp. Under the diagnosis with imatinib-resistant duodenal gastrointestinal stromal tumors, a second-line therapy with sunitinib was tried. After six weeks, his skin lesion was completely improved and other metastatic cancers showed a response of stable disease. This is the first reported case of a cutaneous metastasis from duodenal GIST. This report emphasizes the importance of a full-skin examination in patients with a medical history of gastrointestinal stromal tumor which leads to find multiple metastases.

References

Apr 19, 2002·Digestive Surgery·Mohsen Shabahang, Alan S Livingstone
Apr 23, 2009·The American Journal of Dermatopathology·Wei-Lien WangAlexander J F Lazar
Apr 26, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L LorenzonS Caterino

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Citations

Sep 10, 2020·Cancer Management and Research·Peng LiuXianhui Zhao
Apr 21, 2021·Orbit·Wesley L BrundridgeDavid E E Holck
Jul 30, 2021·World Journal of Gastrointestinal Oncology·Zhi-Peng ZhouCheng-Gang Li

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Methods Mentioned

BETA
biopsy

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