Abstract
Information regarding the addition of tissue equivalent bolus to adjuvant radiotherapy (RT) for intra-parotid metastatic head and neck cutaneous squamous cell carcinoma is lacking. This study aimed to evaluate the effect of bolus versus no bolus on the patterns of regional and distant recurrence, regional control (RC), cancer-specific survival (CSS), overall survival, RT toxicity and RT interruption. A retrospective study was performed on consecutive patients diagnosed between 1994 and 2008 with metastatic head and neck cutaneous squamous cell carcinoma who were treated with parotidectomy ± selective neck dissection and adjuvant RT ± parotid bolus. Seventy-five patients were identified: 64 males and 11 females, with median age of 79 years (range 40-96) of which 39 had bolus during RT. Median follow up was 48 months (range 4-177). There were 23 regional recurrences - 14 dermal, six dermal + nodal and three isolated nodal - and only two systemic recurrences. Nine patients had RT interruption >6 days due to acute skin toxicity. Bolus was associated with increased grade ≥3 radiation dermatitis (P = 0.02). RT interruption >6 days was significantly associated with inferior RC and hazard ratio, 2.83 (95% confidence interval: 1.04-7.71...Continue Reading
References
Sep 1, 1992·The Australian and New Zealand Journal of Surgery·M G JosephP J Kennedy
Aug 16, 2001·Head & Neck·C J O'BrienC S Lauer
Mar 19, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Basil S CherpelisPearon G Lang
May 10, 2002·Head & Neck·Christopher J O'BrienMichael A Jackson
Jun 13, 2002·Australasian Radiology·Margaret S-T ChuaKenneth W Tiver
Feb 1, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J A D JolA J M Balm
Jul 23, 2003·Archives of Otolaryngology--head & Neck Surgery·Carsten E PalmeGary J Morgan
Oct 2, 2003·The Laryngoscope·Michael J VenessIan Kalnins
Aug 3, 2004·Head & Neck·Chris H J TerhaardUNKNOWN Dutch Head and Neck Oncology Cooperative Group
May 4, 2005·The Laryngoscope·Michael J VenessVal Gebski
Aug 23, 2005·Head & Neck·Theodore S HongPaul M Harari
Sep 9, 2005·The Laryngoscope·Brian A MooreGary L Clayman
Jan 31, 2006·Cancer·Jennifer L AndruchowChristopher J O'Brien
Nov 23, 2006·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·S Ch'ngS T Tan
Apr 6, 2007·Cancer·José F CarrilloLuis F Oñate-Ocaña
Jun 2, 2007·Journal of Biomedicine & Biotechnology·Michael J Veness
Aug 11, 2007·International Journal of Radiation Oncology, Biology, Physics·Allen M ChenLawrence W Margolis
Oct 14, 2008·The Laryngoscope·Russell W HinermanWilliam M Mendenhall
Jan 7, 2010·Cancer·Veronique-Isabelle ForestChris Milross