PMID: 11333127May 3, 2001Paper

Metastatic lesions in the joint associated with acute inflammatory arthritis after dendritic cell immunotherapy for metastatic melanoma

Melanoma Research
R ThomasMark Smithers

Abstract

A 47 year old man undergoing immunotherapy for metastatic melanoma with autologous dendritic cells pulsed with autologous tumour peptide and hepatitis B surface antigen developed acute left ankle arthritis. Gout and acute infection were excluded, and an autoimmune aetiology or occult metastasis were considered. The arthritis initially subsided with indomethacin, but the symptoms recurred 2 months later, and magnetic resonance imaging demonstrated metastatic melanoma of the left talus. Immunohistochemical staining of a cerebral metastatic deposit biopsied 1 week after the onset of arthritis demonstrated T-cell and macrophage infiltration of the tumour. In addition, the patient developed melanoma-specific delayed type hypersensitivity and cytotoxic T-cell responses after vaccination. Thus, the monoarthritis represented an 'appropriate' inflammatory response directed against metastatic melanoma.

References

Jan 10, 1987·Lancet·A KeatD Taylor-Robinson
Jul 22, 1971·The New England Journal of Medicine·E AlpertP H Schur
Feb 12, 1998·The Journal of Experimental Medicine·G Schuler, R M Steinman
Jul 15, 1998·Clinical Science·J S Gaston
Sep 17, 1998·The Journal of Clinical Investigation·L W WeberA N Houghton
Dec 4, 1998·Springer Seminars in Immunopathology·R Thomas

❮ Previous
Next ❯

Citations

Jun 19, 2004·Cytotherapy·S B Ingram, M G O'Rourke
Nov 15, 2019·Cancer·Justine V CohenPriscilla K Brastianos
Jan 10, 2020·Pigment Cell & Melanoma Research·Isabella C GlitzaPeter Forsyth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.