Metastatic lymph node in gastric cancer; is it a real distant metastasis?

BMC Cancer
Do Hyoung LimWon Ki Kang

Abstract

Currently, the TNM staging system is a widely accepted method for assessing the prognosis of the disease and planning therapeutic strategies for cancer. Of the TNM system, the extent of lymph node involvement is the most important independent prognostic factor for gastric cancer. The aim of our study is to evaluate the survival and prognosis of gastric cancer patients with LN#12 or #13 involvement only and to assess the impact of anatomic regions of primary gastric tumor on survival in this particular subset of patients. Among data of 1,008 stage IV gastric cancer patients who received curative R0 gastrectomy, a total of 79 patients with LN#12 (n = 68) and/or #13 (n = 11) were identified. All patients performed gastrectomy with D2 or D3 lymph node dissection. In 79 patients with LN#12/13 involvement, the estimated one-, three- and five-year survival rate was 77.2%, 41.8% and 26.6% respectively. When we compared the patients with LN#12/13 involvement to those without involvement, there was no significant difference in OS (21.0 months vs. 25.0 months, respectively; P = 0.140). However, OS was significantly longer in patients with LN#12/13 involvement only than in those with M1 lymph node involvement (14.3 months; P = 0.001). Ther...Continue Reading

References

Jul 24, 2003·The Surgical Clinics of North America·S Eva SingletaryFrederick L Greene
Sep 27, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael W KattanMurray F Brennan
Mar 26, 2004·American Journal of Surgery·Heriberto Medina-FrancoJavier Alvarez-Tostado Ugarte
Apr 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H H HartgrinkM Sasako
Jun 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Takeshi SanoKunio Okajima
Sep 24, 2004·Journal of Surgical Oncology·Junuk KimSung Hoon Noh
Dec 22, 2005·World Journal of Surgery·Chew-Wun WuJacqueline Whang-Peng
Jan 10, 2006·Seminars in Oncology·Cornelis J H van de Velde
Apr 1, 2006·The Lancet Oncology·Chew-Wun WuJacqueline Whang-Peng
Jun 20, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Alberto Di LeoGiovanni de Manzoni
Dec 1, 2007·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Hai-Rim ShinKeun-Young Yoo

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Citations

Oct 25, 2013·Journal of Gastric Cancer·Hyeong Won YuHyung-Ho Kim
Jan 30, 2014·Arquivos De Gastroenterologia·Wilson Luiz da Costa JuniorAlessandro Landskron Diniz

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