PMID: 3167804Nov 1, 1988Paper

Metastatic medullary thyroid carcinoma. Complete response to combination chemotherapy with dacarbazine and 5-fluorouracil

Cancer
S R Petursson

Abstract

A 20-year-old woman had a sporadic case of medullary thyroid carcinoma (MTC) metastatic to the lungs. After a transient response to streptozotocin and doxorubicin, new subcutaneous lesions appeared on the left chest wall and there was progression of pulmonary disease. Because MTC is one of the amine precursor uptake and decarboxylation (APUD) tumors, treatment was undertaken with agents active in these diseases. Dacarbazine and 5-fluorouracil, given daily for 5 days every 4 weeks, resulted in complete resolution of pulmonary and subcutaneous lesions and a sharp decrease in tumor marker levels that lasted 10 months. Recurrence of the pulmonary disease lead to her death 21 months after presentation. Thus, the chemo-responsiveness of MTC may be akin to that of other APUD carcinomas (APUDomas) and treatment of metastatic MTC and other APUDomas with the combination of dacarbazine and 5-fluorouracil appears to merit further study.

References

Jan 1, 1977·Journal of Surgical Oncology·A KessingerJ F Foley
Jan 1, 1979·Annals of Internal Medicine·G M StraussT T Aoki
Jun 1, 1979·Cancer·C M FrauenhofferA Cobanoglu
May 1, 1977·Cancer·R M O'BryanB Hoogstraten
Mar 1, 1975·Cancer·G C ChongL H Woolner
Jun 1, 1985·Cancer·K S SridharT Ohnuma
Oct 1, 1971·Seminars in Nuclear Medicine·L B Woolner
May 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A G Pearse
Jan 1, 1984·Annual Review of Medicine·R N Schimke
Nov 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C G Moertel
Nov 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P F EngstromH O Douglass
Sep 1, 1980·Annals of Internal Medicine·S P MarynickL A Duncan
Jan 1, 1981·Journal of Surgical Oncology·A E AwrichW S Fletcher
Mar 1, 1983·Cancer·A KessingerH M Lemon
Jun 27, 1964·Nature·G V FOSTERI MACINTYRE

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Citations

Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·H ScherüblR Ziegler
Feb 1, 1996·Annals of Nuclear Medicine·L ViniV R McCready
Jun 12, 2002·Current Treatment Options in Oncology·E Kebebew, O H Clark
Oct 1, 1995·Thyroid : Official Journal of the American Thyroid Association·D J MarshB G Robinson
May 28, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association Guidelines Task ForceSamuel A Wells
Jun 22, 2007·Anti-cancer Drugs·Sana Intidhar LabidiPatrice Viens
Nov 8, 2012·Future Oncology·Concetto RegalbutoVincenzo Pezzino
Jun 6, 2007·Hematology/oncology Clinics of North America·Ana O Hoff, Paulo M Hoff
Nov 30, 2006·Journal of Surgical Oncology·Elizabeth A Fialkowski, Jeffrey F Moley
Jun 20, 2014·Cancer·Jessica E MaxwellJames R Howe
Jan 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·T D NguyenG Chaplain
Mar 27, 2015·Thyroid : Official Journal of the American Thyroid Association·Samuel A WellsUNKNOWN American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma
Jul 16, 2010·Clinical Oncology : a Journal of the Royal College of Radiologists·F PaciniM Schlumberger
May 18, 2016·Endocrine-related Cancer·Christine SpitzwegKeith C Bible
Mar 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-François ChatalUNKNOWN French Endocrine Tumor Group
Jun 8, 2004·Endocrine Reviews·Gregory A KaltsasAshley B Grossman
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·K KaczirekB Niederle
Nov 3, 2005·The Journal of Clinical Endocrinology and Metabolism·Christopher J StrockBarry D Nelkin
Apr 13, 2006·The Journal of Clinical Endocrinology and Metabolism·J FromiguéM Schlumberger
Apr 17, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Maran IlanchezhianJaydira Del Rivero
Nov 12, 2019·International Journal of Clinical Endocrinology and Metabolism·Apoorva JayarangaiahSamy I McFarlane

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