Metastatic Melanoma presenting 24 years after surgical resection: a case report and review of the literature.

Cases Journal
Eoin Slattery, Diarmuid O'Donoghue

Abstract

Malignant Melanoma is becoming increasingly common. Recurrence is common in, with late recurrence up to 10 years being recognised. We present a case of recurrent metastatic melanoma 24 years after initial presentation, which is the longest interval reported to date. EF presented with iron-deficiency anaemia, lethargy, and weight loss. He had an enucleation of his left eye 24 years previously for a uveal melanoma. Endoscopy and biopsy confirmed recurrent duodenal and gastric metastasis. A staging CT demonstrated wide spread thoracic, liver, adrenal and bone metastasis. He was treated with palliative chemotherapy, and died 3 months later. Late presentation of metastatic melanoma is common, and should be remembered in patients with a distant history of melanoma. Even, as in our case, if the history is more than two decades previously. Treatment options are poor; earlier recognition may lead to improved survival.

References

Mar 1, 1991·Ophthalmology·E S GragoudasM D Spar
Jun 20, 2007·Current Oncology·I QuirbtUNKNOWN Members of the Melanoma Disease Site Group of Cancer Care Ontario's Program in Evidence-Based Care
Oct 15, 2008·Archives of Ophthalmology·Gianni VirgiliUNKNOWN EUROCARE Working Group
Apr 28, 2009·Journal of the American Academy of Dermatology·Deepak K PruthiAlain A Demers

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Citations

Dec 7, 2010·Indian Journal of Cancer·M S Walid, M Sanoufa
Feb 18, 2016·Journal of Cancer Research and Therapeutics·Sanchayan MandalSubhra Sil
Apr 19, 2015·BMC Research Notes·Constantine HalkiasGareth Bashir
Jul 14, 2012·The American Journal of Surgical Pathology·Iwei YehKlaus J Busam
Jun 21, 2018·Acta Oncologica·Gianni GerliniLorenzo Borgognoni

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Methods Mentioned

BETA
X-ray
biopsies

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