Metastatic melanoma: the spectrum of ultrastructural morphology

Ultrastructural Pathology
M T Mazur, A L Katzenstein

Abstract

The fine structure of 26 metastatic melanomas, including 13 pigmented and 13 amelanotic tumors, as studied to define ultrastructural criteria for diagnosis. Several important features in addition to melanosome granules were identified. Dendritic cytoplasmic processes were seen in 25 of the 26 cases, cell clusters formed by concentric aggregates of several cells and their processes were present in 18, and microvilli were found on cell surfaces in all cases. The cytoplasm was complex, containing numerous mitochondria, Golgi systems, endoplasmic reticulum, nonspecific filaments, and microtubules. Nuclear morphology was variable. Basement membranes and cell junctions including desmosomes were often encountered, and some melanomas shared features with Schwann cells, including complex membrane interdigitations. All tumors contained melanosomes, although the classic forms were frequently difficult to identify and abnormal variant forms often predominated. Knowledge of the variant melanosome morphology and an understanding of the other fine structural features of malignant melanocytes can help identify those cases that lack classic premelanosome granules.

References

Jan 1, 1977·Advances in Cancer Research·W H ClarkE A Bernardino
Apr 1, 1978·The Journal of Pathology·P H Carstens, W L Broghamer
Apr 1, 1978·Cancer·D Boudreaux, J Waisman
Sep 1, 1976·Beiträge Zur Pathologie·D S BonikosR L Kempson
May 1, 1968·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A B NovikoffL Biempica
Aug 1, 1971·American Journal of Surgery·R B GrieppN E Shumway
Aug 1, 1969·American Journal of Clinical Pathology·H A Rodriguez, M H Mcgavran
Apr 1, 1972·The British Journal of Dermatology·H Klug, W Günther
Jan 1, 1980·Ultrastructural Pathology·B Mackay, A G Ayala
Dec 1, 1959·Journal of Ultrastructure Research·S R WELLINGS, B V SIEGEL
Dec 1, 1962·The Journal of Investigative Dermatology·A S ZELICKSON

Citations

Jun 1, 1988·Cancer Metastasis Reviews·A BomirskiJ Bigda
Nov 1, 1994·Journal of the American Academy of Dermatology·N S HouseK F Helm
Dec 3, 1999·Histopathology·A V Vallat-DecouvelaereJ Mikol
Jun 27, 2006·Journal of Clinical Pathology·Philip C W LuiAye T Khin
Jan 1, 1985·Ultrastructural Pathology·R A Erlandson
Jan 1, 1987·Ultrastructural Pathology·M YamashinaR DuBrow
Jan 1, 1987·Ultrastructural Pathology·U J van Haelst, R Holland
Sep 1, 1992·Ultrastructural Pathology·P H Carstens, J L Hollander
Jan 1, 1993·Ultrastructural Pathology·I DardickG Perkins
Nov 7, 1998·Ultrastructural Pathology·F AlamedaS Serrano
Mar 1, 1995·Ultrastructural Pathology·V Vicente OrtegaG Ortuño Pacheco
Jan 1, 1985·Ultrastructural Pathology·J D BensonB Mackay
Mar 1, 1989·Ultrastructural Pathology·R A Erlandson
Apr 1, 1982·European Journal of Cancer & Clinical Oncology·T SatoK Konno
Feb 1, 1981·Journal of Oral Pathology·J M NeslandM Sobrinho-Simöes
Jan 1, 1983·Histopathology·S G van DuinenE Scheffer
Jan 1, 1984·Ultrastructural Pathology·S Thorstenson
Jun 1, 1996·The Journal of Pathology·G P Cowley, M E Smith
May 18, 1999·The American Journal of Surgical Pathology·S S BanerjeeA N Brain
Aug 15, 1986·Cancer·F A Tavassoli
Sep 11, 2007·Histopathology·S S Banerjee, B Eyden
Dec 1, 1989·Pediatric Dermatology·T K Das GuptaM S Amoss
Jun 23, 2009·The American Journal of Dermatopathology·Denisa KacerovskaDmitry V Kazakov
Oct 1, 1982·Ultrastructural Pathology·H J SobelL I Alpert

Related Concepts

Teens
Protoplasm
Intercellular Junctions
Intestinal Cancer
Malignant Neoplasm of Lung
Lymphatic Metastasis
Melanocyte
Melanoma

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