Metastatic non-muscle invasive bladder cancer with meningeal carcinomatosis: case report of an unexpected response

BMC Cancer
Diego TeyssonneauMarine Gross-Goupil

Abstract

Non-muscle invasive bladder cancer (NMIBC) is usually treated with local therapy including transurethral resection of the bladder tumor and intravesical therapy depending on the stage of the tumor. NMIBC is a rarely a metastatic diseases with lymph node invasion in less of 10%. In the other hand meningeal carcinomatosis is a rare location for metastases with extremely poor outcomes. We described a case report of a patient presenting a metastatic disease to bones and meninges, several years after the treatment of NMIBC, which had been in complete response (CR) for 4 years after chemotherapy treatment. A 63-years old men was treated by TURBT in 2008 for a high grade NMIBC, pT1b. Three years later he presented an acute binocular diplopy with right trochlear nerve paralysis, and labial hypoesthesia. Brain scan and MRI were performed finding a clivus infiltration and a pachymeningitis. A vertebral biopsy was performed finding an invasive carcinoma, CK7+/CK20+, TTF1-, PSA-, Thyroglobulin- and GATA3+. The metastatic event was in relation to the high grade NMIBC treated 3 years previously. Palliative chemotherapy was started with cisplatin gemcitabine. After 6 cycles and to date, 4 years later, the patient is therefore considered in co...Continue Reading

References

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Citations

Oct 24, 2018·Journal of Investigative Medicine High Impact Case Reports·Noah FrydenlundMichael A O'Donnell
Apr 23, 2019·Molecular and Clinical Oncology·Yuta UmezawaMasafumi Oyama
Jan 31, 2019·Oxford Medical Case Reports·Jessica LittleWaqar Saleem
Dec 4, 2021·World Neurosurgery·Felix Jozsa, Joe M Das

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Methods Mentioned

BETA
biopsy

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