Metastatic papillary craniopharyngioma: case study and study of tumor angiogenesis

Neuro-oncology
Lhan ElmaciBernd W Scheithauer

Abstract

We report a case of suprasellar papillary craniopharyngioma metastatic to the temporoparietal region 2 years after its initial resection. The literature documents examples of craniopharyngioma recurrences along the surgical tract, as well as remote ipsi- and contralateral metastases via cerebrospinal fluid seeding. Ours is the second report of a craniopharyngioma of papillary type to exhibit metastatic behavior. The tumor spread opposite the side of craniotomy. Although a rare occurrence, it confirms the limited capacity of histologically benign craniopharyngiomas to undergo meningeal seeding, likely the result of surgical manipulation. Immunohistochemical demonstration of increased microvascular density and vascular endothelial growth factor expression, as well as a high vascular endothelial growth receptor (VEGFR2) signal by in situ hybridization, suggests that tumor vascularity facilitated angiogenesis and may have been involved in the establishment and growth of the metastatic deposit.

References

Jul 1, 1978·Journal of Neurosurgery·H MajlessiA Katirai
Apr 1, 1976·Cancer·C K PetitoK M Earle
Nov 1, 1992·Journal of Neurosurgery·J M MalikS R VandenBerg
Sep 1, 1991·Neurosurgery·H Z GökalpK Bacaci
Apr 1, 1991·Journal of Neurosurgery·A T Ragoowansi, D G Piepgras
Jul 1, 1990·Journal of Neurosurgery·T E AdamsonM G Yaşargil
Jul 1, 1990·Journal of Neurosurgery·M G YaşargilP Roth
Feb 1, 1988·Neurosurgery·G A NelsonR L White
Jan 1, 1972·Journal of Neurosurgery·P R Cooper, J Ransohoff
Jul 1, 1983·Journal of Neurosurgery·T A Duff, R Levine
Aug 1, 1995·Journal of Neurosurgery·T B CrottyP C Burger
Apr 8, 1999·Journal of Neurosurgery·J H LeeH W Jung
Nov 30, 1999·Journal of Neurosurgery·J VaqueroC Salas
Feb 26, 2000·Neurosurgery·J DuffB W Scheithauer
Jul 27, 2001·Virchows Archiv : an International Journal of Pathology·S VidalR V Lloyd
Jul 13, 2002·Endocrine Pathology·Ricardo V. LloydLucia Stefaneanu

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Citations

Nov 26, 2009·Journal of Neuro-oncology·Jianguo XuNi Chen
Feb 28, 2006·Clinical Neurology and Neurosurgery·Martha Lilia Tena-SuckOscar Arrieta
Jul 11, 2006·Ultrastructural Pathology·Lucio AgozzinoLuigi Cuccurullo
Feb 5, 2009·Neurosurgery·Kerem BikmazMuhammad M Husain
Jun 30, 2018·Journal of Neurosurgery. Pediatrics·Jaclyn J RenfrowDaniel E Couture

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