PMID: 8941011Dec 1, 1996Paper

Metastatic phenotype correlates with high expression of membrane-associated complete beta-human chorionic gonadotropin in vivo

Cancer
H F Acevedo, R J Hartsock

Abstract

Investigations using living human cancer cells and the nude mouse model were conducted to evaluate the expression of human chorionic gonadotropin (hCG) in various cancers grown in vitro and in vivo. The aim was to determine whether membrane-associated hCG in any of its forms is a characteristic metastatic marker, and at what levels or ratios. Human cancer cell lines known to produce tumors that metastasize spontaneously when grown in nude mice (n = 4) were compared with those that do not produce such tumors (n = 4) using analytical (quantitative) flow cytometry. Monoclonal antibodies directed to epitopes of intact hCG (hCG-holo) and its subunits, including beta-human chorionic gonadotropin with its carboxy-terminal peptide (hCG beta-CTP), allowed for the determination of hCG beta-CTP/hCG-holo ratios. No significant difference in hCG beta-CTP/hCG-holo ratios was found between the cultured human cancer cells that do not metastasize spontaneously (ratio = 2.39) and those that do (ratio = 2.13), and no difference was seen in their growth rate in nude mice. However, the cells isolated from tumors that do not metastasize spontaneously showed a decrease in their ratios to values less than 1. They reverted to their original values afte...Continue Reading

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Citations

Jan 28, 2009·Reproductive Biology and Endocrinology : RB&E·Laurence A Cole
Aug 17, 2011·Reviews in Endocrine & Metabolic Disorders·Prajna Banerjee, Asgerally T Fazleabas
Dec 14, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Laurence A Cole
May 8, 2010·Expert Opinion on Biological Therapy·Susanna Lintula, Kristina Hotakainen
Feb 14, 2015·Taiwanese Journal of Obstetrics & Gynecology·Yi LuXinyan Liu
Nov 15, 2008·Gynecologic Oncology·Carolyn Y Muller, Laurence A Cole
Nov 22, 2011·Molecular and Cellular Endocrinology·Laurence A Cole, Stephen Butler
Oct 27, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Laurence A Cole
Mar 10, 2001·International Journal of Cancer. Journal International Du Cancer·M LundinC Haglund
Mar 14, 2018·International Journal of Surgical Pathology·Elena MaryamchikAndrew E Rosenberg
May 10, 2002·Breast Cancer Research and Treatment·Sunthorn Pond-TorAlbert E Dahlberg

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