Metastatic potential and prognostic significance of SOX2: A meta-analysis

World Journal of Clinical Oncology
Arslaan Javaeed, Sanniya Khan Ghauri

Abstract

SOX2 is a regulator of pluripotent cellular transcription, yet it has been recently integrated in cancer biology. The present study provides an analytic insight into the correlation of SOX2 overexpression with cancer metastasis and patient survival. To investigate the association of SOX2 overexpression with metastasis and its implication in the prognosis of cancer patients. A meta-analysis was conducted including studies that compared the association of low or high SOX2 expression with lymph node metastasis (LNM) and/or distant metastasis (DM). The following data were additionally extracted: survival, including the overall survival (OS) and disease-free survival (DFS), and prevalence of high and low SOX2 expression. Odds ratios (commonly known as ORs) and their respective 95% confidence intervals (CIs) were used to investigate the association between SOX2 expression and LNM and DM, while hazard ratios (commonly known as HRs) and 95%CIs were applied to evaluate the prognostic markers. In a total of 2643 patients (60.88% males), the pooled prevalence of SOX2 overexpression was 46.22% (95%CI: 39.07%-53.38%) in different types of cancer. SOX2 overexpression significantly correlated with DM (OR = 1.79, 95%CI: 1.20-3.25, P < 0.008) c...Continue Reading

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Citations

Dec 8, 2019·Pathology, Research and Practice·Xian-Hui ZhangLan Ma
May 19, 2021·Matrix Biology : Journal of the International Society for Matrix Biology·Miriam Gross-CohenIsrael Vlodavsky
Aug 11, 2021·Pharmaceutics·Adriana G Quiroz-ReyesElsa N Garza-Treviño
Aug 27, 2021·Current Oncology·Zahra Hosseini-KhahBehrooz Nikbin

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