Metastatic Potential of Grade I Chondrosarcoma of Bone: Results of a Multi-institutional Study

Annals of Surgical Oncology
Dimosthenis AndreouArne Streitbürger

Abstract

Little is known about the metastatic potential of low-grade chondrosarcoma. This study was designed to evaluate the rate of metastasis to identify possible risk factors. The files of 225 patients with newly diagnosed, grade I chondrosarcoma of bone treated between 1975 and 2012 were retrospectively analyzed. Median follow-up was 80 months for survivors (range 24-445 months). Nonparametric analyses were performed with the Mann-Whitney U test. Survival curves were calculated with the Kaplan-Meier method and compared with the log-rank test. Fourteen patients developed metastases after a median of 49 months. Metastasis-free survival probability (MFS) was 95 % at 5 years and 92 % at 10 years. Post-metastasis survival probability amounted to 27 % after 5 years. Tumor size at diagnosis (P = 0.698) and surgical margin width (P = 0.514) had no influence on MFS. Patients who developed local recurrences had a significantly lower 10-year MFS than patients without recurrences (69 % vs. 99 %, P < 0.001). Patients with grade I recurrences had a significantly poorer MFS than patients without recurrences (P = 0.013) but a significantly higher MFS than patients with grade II recurrences (P = 0.006). Patients with thoracic wall tumors had a signi...Continue Reading

References

May 22, 2007·Clinical Orthopaedics and Related Research·Joseph H SchwabFranklin H Sim
Jul 17, 2007·Clinical Orthopaedics and Related Research·Taninnit LeerapunFranklin H Sim
Oct 3, 2007·The Journal of Bone and Joint Surgery. American Volume·UNKNOWN Skeletal Lesions Interobserver Correlation among Expert Diagnosticians (SLICED) Study Group
Apr 2, 2008·The Oncologist·Hans GelderblomJudith V M G Bovée
Oct 15, 2008·The American Journal of Surgical Pathology·Daniël EeftingUNKNOWN EuroBoNeT consortium
Oct 16, 2008·Journal of Cancer Research and Clinical Oncology·Arne StreitbürgerJendrik Hardes
Dec 17, 2009·Archives of Internal Medicine·Amy Berrington de GonzálezCharles Land
Aug 31, 2010·International Orthopaedics·Philipp T FunovicsMartin Dominkus
Jul 5, 2012·The Journal of Bone and Joint Surgery. American Volume·Suzan H M VerdegaalAntonie H M Taminiau
Mar 7, 2013·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Domenico Andrea CampanacciRodolfo Capanna
May 9, 2013·The Journal of Laryngology and Otology·J HussemanR Briggs
Aug 15, 2013·Current Opinion in Oncology·Andrew E Rosenberg
Nov 20, 2013·Clinical Orthopaedics and Related Research·Ajay PuriRajendra A Badwe

❮ Previous
Next ❯

Citations

Oct 4, 2016·Journal of Surgical Oncology·Claudia DeckersIngrid C M van der Geest
Dec 21, 2017·Der Pathologe·G Jundt
Apr 28, 2018·The Bone & Joint Journal·M K LaitinenL M Jeys
Oct 1, 2019·The Bone & Joint Journal·Yusuke TsudaSeggy Abudu
Dec 27, 2019·Archives of Pathology & Laboratory Medicine·David SusterG Petur Nielsen
Sep 5, 2019·World Journal of Surgical Oncology·Julian FrommHans Roland Dürr
Aug 26, 2018·BMC Cancer·Julian FrommHans Roland Dürr
Aug 20, 2019·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·S S JassimR Pollock
Mar 30, 2020·Journal of the Chinese Medical Association : JCMA·Yi-Chou ChenWei-Ming Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.