Metastatic prostatic adenocarcinoma mimicking inflammatory breast carcinoma: a case report

Clinical Breast Cancer
Uchenna O Njiaju, Cristina I Truica

Abstract

Prostate adenocarcinoma can manifest as a fairly indolent tumor or as a very aggressive cancer with significant invasive and metastatic potential. Common metastatic sites include bone, liver, lymph nodes, and adrenal glands. Dermatologic manifestations are rare. We present a case of a man who presented with breast skin changes that mimicked inflammatory breast carcinoma with specialized testing ultimately giving a diagnosis of metastatic prostatic adenocarcinoma. A 78-year-old man presented with left breast redness and swelling. Examination revealed an erythematous rash with subcutaneous edema over the left hemithoracic area. A breast ultrasound showed no focal mass, and a breast core biopsy had no evidence of tumor. A skin biopsy showed metastatic carcinoma in dermal lymphatics, and the tumor was found to have no estrogen or progesterone receptors or HER2 expression. Computed tomography scans, positron emission tomography, and a nuclear bone scan revealed widespread skeletal metastases. The patient received a 3-month course of capecitabine and cyclophosphamide with no improvement in his skin lesions. Subsequent immunohistochemical staining on the tumor specimen was positive for prostate-specific antigen (PSA) and alpha-methyl-...Continue Reading

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Citations

Oct 31, 2012·Case Reports in Oncology·Renaud SabatierFrançois Bertucci
Apr 11, 2015·Case Reports in Urology·Parth PatelSameer Siddiqui
Jun 27, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ricardo H AlvarezVicente Valero
Sep 10, 2014·Orvosi hetilap·Zoltán Mátrai, Ferenc Rényi Vámos
May 24, 2012·The American Journal of Dermatopathology·Inmaculada AlcarazLuis Requena
May 23, 2019·The American Journal of Tropical Medicine and Hygiene·Gianluca QuaglioPiero L Olliaro
Jan 4, 2019·Archives of Pathology & Laboratory Medicine·Gabriel Habermehl, Jennifer Ko

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