Metastatic seminoma and grade 1 follicular lymphoma presenting concurrently in a supraclavicular lymph node: a case report.

Cases Journal
Eric JacobsenWilliam K Oh

Abstract

An asymptomatic 67-year-old man presented with a left supraclavicular lymph node that enlarged over a 2-month period which was biopsied. Pathologic features were consistent with involvement by metastatic seminoma and follicular lymphoma, follicular pattern, grade 1 (of 3). Staging Positron Emission Tomography/Computed Tomography scans indicated several areas of enlarged lymph nodes. The patient completed chemotherapy with bleomycin, etoposide, and cisplatin chemotherapy. This is the first reported case of metastatic seminoma and follicular lymphoma occurring in the same lymph node. No obvious pathophysiologic link exists between these two malignancies and there are no shared common risk factors. Given the natural history of these two malignancies, if this patient develops recurrent lymphadenopathy, it will be difficult to identify whether the enlarged lymph nodes represent recurrent seminoma or follicular lymphoma without a biopsy of each pathologically enlarged node. Similarly, Fluorodeoxyglucose- Positron Emission Tomography is known to be active in both seminoma and follicular lymphoma, making this scan non-specific in this patient. Finally, this patient had no baseline elevation in any germ cell tumor marker. Thus, serum tu...Continue Reading

References

Mar 17, 2004·World Journal of Urology·Maria De Santis, Jörg Pont
Sep 2, 2008·Seminars in Hematology·Jonathan W Friedberg
Oct 29, 2008·Hematology/oncology Clinics of North America·Bruce D Cheson

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Citations

Jan 15, 2016·Journal of Clinical and Experimental Hematopathology : JCEH·Junichi KitagawaHisashi Tsurumi
Oct 22, 2021·Journal of Pathology and Translational Medicine·Kosuke MiyaiHitoshi Tsuda

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Methods Mentioned

BETA
biopsy

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