Metastatic Spinal Cord Compression from Non-Small-Cell Lung Cancer Treated with Surgery and Adjuvant Therapies: A Retrospective Analysis of Outcomes and Prognostic Factors in 116 Patients

The Journal of Bone and Joint Surgery. American Volume
Yu TangJianru Xiao

Abstract

Metastatic spinal cord compression is a disastrous consequence of non-small-cell lung cancer (NSCLC). There have been few studies of the outcomes or prognostic factors in patients with metastatic spinal cord compression from NSCLC treated with surgery and adjuvant therapies. From 2002 to 2013, 116 patients with metastatic spinal cord compression from NSCLC treated with surgery and adjuvant therapies were enrolled in this retrospective analysis. Kaplan-Meier methods and Cox regression analysis were used to estimate overall survival and identify prognostic factors for survival. Multivariate analysis suggested that the Eastern Cooperative Oncology Group performance status (ECOG-PS), preoperative and postoperative Frankel scores, postoperative adjuvant radiation therapy, and target therapy were independent prognostic factors. Ninety patients died at a median of twelve months (range, three to forty-seven months) postoperatively, and twenty-six patients were still alive at the time of final follow-up (at a median of fifteen months [range, five to fifty-four months]). The complete disappearance of deficits in spinal cord function after surgery was the most robust predictor of survival. Adjuvant radiation therapy and target therapy wer...Continue Reading

Citations

Sep 17, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nuno BatistaCharles Fisher
Sep 25, 2016·The Spine Journal : Official Journal of the North American Spine Society·Syed K MehdiThomas E Mroz
Dec 28, 2016·Cancer·M Loreto YáñezTracy T Batchelor
Jan 20, 2018·Journal of Neuro-oncology·Xin GaoJianru Xiao
Jan 20, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Yujie LiuJianru Xiao

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