Metastatic spinal cord compression in non-small cell lung cancer patients. Prognostic factors in a series of 356 patients.

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Dirk RadesSteven E Schild

Abstract

Patients with metastatic spinal cord compression (MSCC) from non-small cell lung cancer (NSCLC) have an unfavorable prognosis compared to most other MSCC patients. This study was performed to identify prognostic factors for functional outcome and survival in these patients after radiotherapy (RT) alone. Data of 356 patients irradiated for MSCC from NSCLC were retrospectively analyzed. Ten potential prognostic factors were investigated including age, gender, Eastern cooperative Oncology Group performance score (ECOG-PS), number of involved vertebrae, pre-RT ambulatory status, other bone metastases, visceral metastases, interval from cancer diagnosis to RT of MSCC, time developing motor deficits before RT, and the radiation schedule. On multivariate analysis, better functional outcome was associated with pre-RT ambulatory status (estimate: - 0.84, p = 0.022), no visceral metastases (estimate: - 1.15, p < 0.001), interval from cancer diagnosis to RT of > 15 months (estimate:  + 0.48, p = 0.019), and slower (> 7 days) development of motor deficits (estimate:  + 1.56, p < 0.001). On multivariate analysis, improved survival was significantly associated with female gender (risk ratio (RR) 1.32, p = 0.043), ECOG-PS 1-2 (RR 1.45, p = 0....Continue Reading

References

Aug 1, 1985·Journal of Neurosurgery·A KatoH Mogami
Jan 1, 1983·Acta Radiologica. Oncology·T TomitaN Sundaresan
Apr 4, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Dirk RadesPeter J Hoskin
Nov 7, 2006·International Journal of Radiation Oncology, Biology, Physics·Dirk RadesJuergen Dunst
Apr 1, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Katja FreundtDirk Rades
May 11, 2010·International Journal of Radiation Oncology, Biology, Physics·Dirk RadesSteven E Schild
Sep 3, 2010·Nature Reviews. Clinical Oncology·Dirk Rades, Janet L Abrahm
Feb 5, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Toshihiko InoueHiroya Shiomi
Jun 30, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Matthias UhlKlaus Herfarth
Jun 30, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Florian StielerFrank Lohr
Feb 23, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·D RadesS E Schild

❮ Previous
Next ❯

Citations

Feb 19, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·D RadesS E Schild
Apr 23, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·D RadesS E Schild
Sep 21, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·H RiefJ Debus
Feb 18, 2015·The Spine Journal : Official Journal of the North American Spine Society·Gustavo T SilvaLuiz C S Thuler
Sep 17, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nuno BatistaCharles Fisher
Dec 19, 2016·The Spine Journal : Official Journal of the North American Spine Society·Panya LuksanapruksaAreesak Chotivichit
Jan 19, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Carsten NiederAstrid Dalhaug
Jan 30, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Fahed ZairiRichard Assaker
Jul 30, 2015·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Gustavo Telles da SilvaLuiz Claudio Santos Thuler
Apr 1, 2020·Orthopaedic Surgery·Deng-Xing LunYong-Cheng Hu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Dirk RadesSteven E Schild
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Dirk RadesSteven E Schild
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Dirk RadesSteven E Schild
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Dirk RadesSteven E Schild
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Dirk RadesSteven E Schild
© 2022 Meta ULC. All rights reserved