PMID: 8989940Dec 1, 1996Paper

Metastatic testicular choriocarcinoma of the skin. Report and review of the literature

The American Journal of Dermatopathology
S ShimizuH Han-yaku

Abstract

Choriocarcinoma is a malignant growth of trophoblastic cells characterized by secretion of human chorionic gonadotropin. Choriocarcinoma usually arises from fetal trophoblasts and rarely arises from germ cells in the testis or ovary or derives from dedifferentiation of other carcinomas. Skin metastasis of choriocarcinoma is rare: only seven cases have been reported in the English and Japanese literature. We report the case of a 22-year-old Japanese man with pure choriocarcinoma of the testis who developed skin metastases that presented as multiple reddish nodules. Microscopic examination of both the primary lesion of the testis and the cutaneous metastasis demonstrated the typical histologic features of pure choriocarcinoma. The patient died 3 months after the initial onset of skin metastasis. Review of the literature indicates that skin metastasis of choriocarcinoma usually occurs as a nodular lesion with the histologically typical feature of the primary disease and signals of poor prognosis.

References

May 1, 1991·The Journal of Dermatologic Surgery and Oncology·L RequenaE Sánchez Yus
Apr 1, 1974·Archives of Dermatology·I Cosnow, D F Fretzin
Aug 1, 1982·American Journal of Obstetrics and Gynecology·E ErtüngealpA Sedlis

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Citations

Nov 24, 2006·The American Journal of Dermatopathology·Eve MaubecChristine Theodore
Jun 24, 2010·The American Journal of Dermatopathology·Cornelia S L MüllerNorbert Graf
May 24, 2012·The American Journal of Dermatopathology·Inmaculada AlcarazLuis Requena
Sep 4, 2012·Journal of Medical Case Reports·Mustapha AhsainiAmal Amarti
Jun 1, 2010·American Journal of Clinical Dermatology·Heather M RichmondDeborah F Macfarlane
Feb 6, 2014·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Anjana JoelRaju Titus Chacko
Jun 9, 2004·Urology·Thomas J MuellerRobert G Uzzo
Dec 25, 2007·The British Journal of Oral & Maxillofacial Surgery·Arnaud GleizalJean-Luc Béziat
Mar 6, 2007·The Journal of Hand Surgery·Ahmadreza AfsharShirin Lotfinejad
Apr 18, 2018·Journal of Cutaneous Pathology·Ferdinand TobererCarsten Grüllich
Feb 15, 2001·The Journal of Urology·S DuelandJ Iversen
Nov 7, 2008·International Journal of Dermatology·Asli Altaykan HapaHüseyin Ustün
Aug 16, 2005·Journal of Korean Medical Science·Sang Gun ParkDongsik Bang
Dec 20, 2005·International Urology and Nephrology·Mustafa SofikerimHaluk Ozen

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