Metastatic uterine leiomyosarcomas: a single-institution experience

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Rinat Bernstein-MolhoOfer Merimsky

Abstract

Uterine leiomyosarcoma (LMS) is a rare disease and, when it recurs or metastasizes, can rarely be cured. In a retrospective study, we summarized our experience in treating a large cohort of patients with metastatic uterine LMS. Cases of recurrent or metastatic uterine LMS diagnosed between 2000 and 2008 were analyzed. Survival was determined from the time of initial diagnosis to last follow-up. Thirty-three patients (median age, 55 years) were identified. Eighteen patients were initially diagnosed with localized disease. Median disease-free interval was 5.25 months, and overall survival (OS) is 43.7 months. Median OS of 15 patients with initially discovered metastatic disease is 31.4 months. Different chemotherapy regimens produced approximately 30% response rates. Twelve patients underwent at least 1 surgical resection of pulmonary or extrapulmonary metastases. In this group, median progression-free survival was 7.9 months (range, 0-33.9 months), median OS was 45.2 months (range, >8.1-78.8 months), 2-year survival rate was 83%, and 4-year survival rate was 25%. Very few patients with recurrent or metastatic uterine LMS can be curatively treated. Our experience suggests that modern multimodal therapy or combining chemotherapy w...Continue Reading

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Citations

Jul 22, 2014·International Journal of Surgical Oncology·Han L T HoangJoseph S Raccuia
May 30, 2012·Clinical Journal of Oncology Nursing·Tareai Smith, Patricia McLaughlin
Aug 22, 2014·Journal of Gynecologic Oncology·Sree Harsha TirumaniNikhil H Ramaiya
Oct 15, 2018·Oncology Research and Treatment·Falk C Thiel, Sonja Halmen
Oct 16, 2018·Oncology Research and Treatment·Ingolf Juhasz-BössGeorg-Peter Breitbach
Jan 11, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·G MarinielloF Maiuri
Aug 15, 2013·Current Opinion in Oncology·Akiva P Novetsky, Matthew A Powell
Mar 26, 2016·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Carla BartoschJosé M Lopes
Jan 1, 2012·American Society of Clinical Oncology Educational Book·Sharmilee B Korets, John P Curtin
Feb 20, 2016·Molecular and Clinical Oncology·Ying HanLingying Wu

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