Metformin administration modulates neurosteroids secretion in non-obese amenorrhoic patients with polycystic ovary syndrome

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Alessandro D GenazzaniAndrea R Genazzani

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disease that is observed frequently to be related to increased insulin resistance. The use of insulin-sensitizer compounds, such as metformin, permits great improvement of such metabolic abnormality and the restoration of normal ovarian function. Metformin administration reduces insulin resistance and androgen production both from the ovary and adrenal gland. On this basis we aimed to evaluate a group of non-obese amenorrheic PCOS patients before and after 6 months of metformin administration (500 mg per os twice daily) to better understand what changes might be induced by metformin on adrenal and ovarian function and in terms of temporal coupling of the pulsatile profiles of luteinizing hormone (LH), cortisol and allopregnanolone, the latter representative of the neurosteroid family. A group of non-obese PCOS patients (n = 8) was enrolled after informed consent and underwent to a pulsatility study for LH, cortisol and allopregnanolone, and an oral glucose tolerance test before and on day 7 of the first menstrual cycle occurring after the 5th month of treatment. Plasma androgen levels were decreased significantly by metformin treatment, as were plasma LH and allopregnanolon...Continue Reading

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Citations

Jul 6, 2010·Women's Health·Alessandro D GenazzaniChiara Lanzoni
Dec 30, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sahruh TurkmenYucel Cengiz
Sep 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Julia Johansson, Elisabet Stener-Victorin
Apr 12, 2016·Clinical Endocrinology·Sahruh TurkmenTorbjörn Bäckström
Jun 18, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Evangelia BillaDimitrios A Adamopoulos
Jul 23, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Toru TakeuchiYuji Taketani
Jul 14, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Alessandro D GenazzaniAndrea R Genazzani
Mar 14, 2013·American Journal of Physiology. Endocrinology and Metabolism·Julia JohanssonElisabet Stener-Victorin
Apr 22, 2021·Current Psychiatry Reports·Lindsay R StandevenLiisa Hantsoo
Jul 12, 2017·Frontiers in Neuroendocrinology·E HolmbergT Bäckström
Jul 13, 2007·Current Opinion in Obstetrics & Gynecology
Nov 6, 2021·Journal of Neuroendocrinology·Antonella Rosario Ramona CáceresMyriam Raquel Laconi
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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