Metformin administration restores allopregnanolone response to adrenocorticotropic hormone (ACTH) stimulation in overweight hyperinsulinemic patients with PCOS

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
A D GenazzaniA R Genazzani

Abstract

To investigate the adrenal response in terms of allopregnanolone secretion in a group of hyperinsulinemic patients with polycystic ovary syndrome (PCOS). Controlled clinical study. Patients with PCOS in a clinical research environment. Twenty-two overweight patients with PCOS with hyperinsulinism were enrolled after informed consent. All patients underwent hormonal evaluations, oral glucose tolerance test (OGTT) and adrenocorticotropic hormone (ACTH) test before and after 4 months of metformin administration (500 mg p.o. bi-daily). Ultrasound examinations and Ferriman-Gallway score were also performed. Main outcome measures. plasma luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), estradiol, 17-hydroxy-progesterone (17OHP), androstenedione (A), testosterone (T), allopregnanolone, glucose, insulin, C peptide concentrations, body mass index (BMI). Metformin administration reduced significantly LH, A, T, insulin and BMI, while allopregnanolone was significantly increased with no change in progesterone plasma levels. Insulin response to OGTT decreased and allopregnanolone response to ACTH stimulation before while this was restored after the treatment interval. The Ferriman-Gallway score as well as the o...Continue Reading

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Citations

Apr 11, 2014·Molecular Autism·Alexa PohlSimon Baron-Cohen
Mar 13, 2014·The Journal of Obstetrics and Gynaecology Research·Alessandro D GenazzaniTommaso Simoncini
Dec 30, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sahruh TurkmenYucel Cengiz
Mar 8, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Alessandro D GenazzaniTommaso Simoncini
May 23, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Alessandro D GenazzaniPaolo G Artini
Oct 13, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Aleisha M Moore, Rebecca E Campbell
Apr 12, 2016·Clinical Endocrinology·Sahruh TurkmenTorbjörn Bäckström
Nov 2, 2017·Journal of Endocrinological Investigation·A D GenazzaniT Simoncini
Jan 1, 2014·International Journal of Reproductive Medicine·Joselyn RojasValmore Bermúdez
Jul 16, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Alessandro D GenazzaniTommaso Simoncini
Mar 10, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hamidreza JamilianZatollah Asemi
Apr 22, 2021·Current Psychiatry Reports·Lindsay R StandevenLiisa Hantsoo

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