Metformin Affects Gut Microbiota Composition and Diversity Associated with Amelioration of Dextran Sulfate Sodium-Induced Colitis in Mice.

Frontiers in Pharmacology
Zhiyi LiuYing Ying

Abstract

Background: Inflammatory bowel disease (IBD) is an increasingly common and globally emergent immune-mediated disorder. The etiology of IBD is complex, involving multiple factors such as immune dysregulation, environmental factors, genetic mutations, and microbiota dysbiosis, exacerbated by a lack of effective clinical therapies. Recently, studies hypothesized that dysbiosis of intestinal flora might participate in the onset of IBD. Metformin is widely used to treat type 2 diabetes and has shown beneficial effects in mouse models of IBD, although its underlying mechanisms remain poorly understood. Accumulating studies found that metformin shows beneficial effects for diabetes by affecting microbiota composition. This study explores possible regulatory effects of metformin on intestinal microecology during treatment for IBD. Methods: Inflammation was induced using 3% Dextran Sulfate Sodium (DSS) solution to generate mice models of IBD. Metformin treatments were assayed by measuring body weights and colon lengths of mice and H&E staining to observe histological effects on colon tissue structures. Changes in bacterial community composition and diversity-related to IBD and metformin treatment were assessed by high-throughput metagen...Continue Reading

References

Jun 7, 2006·Postgraduate Medical Journal·A-P Bai, Q Ouyang
Sep 28, 2007·International Journal of Medical Microbiology : IJMM·Hiromasa TakaishiToshifumi Hibi
Nov 29, 2011·Clinical Science·Benoit ViolletFabrizio Andreelli
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Amandine EverardPatrice D Cani
Nov 26, 2014·Seminars in Immunopathology·Katsuyoshi Matsuoka, Takanori Kanai
May 15, 2015·Cell Host & Microbe·Marta WlodarskaRamnik J Xavier
Dec 3, 2015·Nature Reviews. Gastroenterology & Hepatology·Heitor S P de Souza, Claudio Fiocchi
Jul 18, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Łukasz BułdakBogusław Okopień
Jul 27, 2017·Nature Reviews. Gastroenterology & Hepatology·Josephine NiVesselin T Tomov
Dec 30, 2017·Clinical Journal of Gastroenterology·Atsushi NishidaAkira Andoh
Sep 25, 2018·Journal of Crohn's & Colitis·Elisabet CantóSilvia Vidal
Sep 24, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wang ZhangQi-Kui Chen

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