PMID: 28504725DOI: 10.1038/nm.4335May 16, 2017Paper
Metformin ameliorates core deficits in a mouse model of fragile X syndrome
Nature Medicine
Ilse GantoisNahum Sonenberg
Abstract
Fragile X syndrome (FXS) is the leading monogenic cause of autism spectrum disorders (ASD). Trinucleotide repeat expansions in FMR1 abolish FMRP expression, leading to hyperactivation of ERK and mTOR signaling upstream of mRNA translation. Here we show that metformin, the most widely used drug for type 2 diabetes, rescues core phenotypes in Fmr1(-/y) mice and selectively normalizes ERK signaling, eIF4E phosphorylation and the expression of MMP-9. Thus, metformin is a potential FXS therapeutic.
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References
May 14, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Brandon C McKinneyWilliam T Greenough
Jul 18, 2006·Pain·Jeffrey S MogilAnna K Naumova
Aug 16, 2006·Neuron·Lingfei HouEric Klann
Mar 24, 2009·Nature Methods·Enrico K SchmidtPhilippe Pierre
Sep 18, 2010·Stroke; a Journal of Cerebral Circulation·Jun LiLouise D McCullough
Nov 26, 2010·Pharmacological Reports : PR·Krzysztof ŁabuzekBogusław Okopień
May 28, 2011·Journal of Neurodevelopmental Disorders·Randi HagermanPaul Hagerman
Jul 10, 2012·Cell Stem Cell·Jing WangFreda D Miller
Oct 23, 2012·Neuron·Aditi BhattacharyaEric Klann
Nov 23, 2012·Nature·Christos G GkogkasNahum Sonenberg
Jan 29, 2013·Neuron·Emily K OsterweilMark F Bear
Feb 26, 2013·PloS One·Heloisa P SoaresEnrique Rozengurt
Apr 11, 2013·Journal of Developmental and Behavioral Pediatrics : JDBP·Mary Jacena S LeighRandi J Hagerman
Jul 5, 2013·American Journal of Medical Genetics. Part a·Magdalena DziembowskaFlora Tassone
Oct 22, 2013·Nature Medicine·Tsuyoshi UdagawaJoel D Richter
Dec 10, 2013·Cell·Elaine Y HsiaoSarkis K Mazmanian
Jul 25, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Harpreet SidhuIryna M Ethell
Jul 30, 2014·Neuroscience Letters·Rin KhangJoo-Ho Shin
Dec 3, 2014·Cell Metabolism·Marc ForetzBenoit Viollet
Dec 4, 2014·Cell Reports·Christos G GkogkasNahum Sonenberg
Dec 11, 2014·PloS One·Ming MingEnrique Rozengurt
Apr 25, 2015·Nature Reviews. Molecular Cell Biology·Hugo Lavoie, Marc Therrien
Dec 4, 2015·Nature·Kristoffer ForslundOluf Pedersen
Jan 15, 2016·Science Translational Medicine·Elizabeth Berry-KravisFlorian von Raison
Feb 6, 2016·Journal of Neurochemistry·Jaspreet SinghShailendra Giri
May 27, 2016·Neuromolecular Medicine·Jing JinWenzhen Duan
❮ Previous
Next ❯
Citations
Dec 9, 2017·Nature Reviews. Drug Discovery·Elizabeth M Berry-KravisSébastien Jacquemont
Sep 25, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Shlomo SragovichIllana Gozes
Nov 23, 2017·Frontiers in Synaptic Neuroscience·Sara CastagnolaThomas Maurin
Jan 30, 2018·Frontiers in Molecular Neuroscience·Rachel M SaréCarolyn B Smith
Dec 21, 2017·F1000Research·Akash RajaratnamRandi Hagerman
Feb 15, 2018·Cold Spring Harbor Perspectives in Biology·Jennifer Chu, Jerry Pelletier
Sep 5, 2018·ELife·Isabelle ArnouxAlbrecht Stroh
Nov 16, 2018·Developmental Neurobiology·Yan-Chu ChenYi-Shuian Huang
Oct 16, 2018·British Journal of Pharmacology·Jun FanFang Wang
Oct 27, 2018·Annual Review of Medicine·Ilse GantoisNahum Sonenberg
Feb 9, 2018·Cell Death & Disease·Chao ZhouJianxin Lyu
Feb 12, 2019·Nature Neuroscience·Minjie ShenXinyu Zhao
Sep 30, 2017·Nature Reviews. Disease Primers·Randi J HagermanPaul J Hagerman
May 20, 2019·Molecular Genetics & Genomic Medicine·Dragana ProticAndrea Schneider
Jun 20, 2017·Nature Reviews. Neuroscience·Darran Yates
Jun 3, 2017·Nature Reviews. Neurology·Heather Wood
Jun 7, 2019·Cellular and Molecular Life Sciences : CMLS·Anna BerounLeszek Kaczmarek
Aug 8, 2018·Cold Spring Harbor Perspectives in Biology·Wayne S Sossin, Mauro Costa-Mattioli
Sep 15, 2019·Molecular Genetics & Genomic Medicine·Hazel Maridith B BiagRandi J Hagerman
Jul 6, 2017·Science Signaling·Leslie K Ferrarelli
Nov 5, 2019·Current Pharmaceutical Design·Michael Telias
Feb 11, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elizabeth A McCullaghYuan Wang
Feb 14, 2020·Stem Cells Translational Medicine·Carl Ernst
Nov 22, 2019·Reviews in the Neurosciences·Bor Luen Tang
May 18, 2020·Fundamental & Clinical Pharmacology·Ismail O IsholaOlufunmilayo O Adeyemi
Jul 29, 2020·Nature Medicine·Ramy AyoubDonald J Mabbott
Dec 18, 2018·Frontiers in Behavioral Neuroscience·Lian WangXiaotang Fan
Jun 5, 2020·Journal of Clinical Medicine·Ilaria ZulianiBianca De Filippis
Jun 27, 2020·Psychopharmacology·Chao LuoXiangping Li
Oct 3, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Tarjani ShuklaZachary T Campbell
Aug 10, 2018·Experimental & Molecular Medicine·Dora C Tărlungeanu, Gaia Novarino
Jun 27, 2019·Current Pediatric Reviews·Dragana ProticRandi J Hagerman
Mar 18, 2020·Communications Biology·Qi DingHongbing Wang
May 22, 2020·Science Translational Medicine·Patrick K McCamphillMark F Bear
Jul 22, 2020·Proceedings of the National Academy of Sciences of the United States of America·Tao ZuLaura P W Ranum
Jun 13, 2020·Journal of Cellular and Molecular Medicine·Yuhong MengQinghua Cui
Aug 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ann Griswold
Dec 28, 2017·Wiley Interdisciplinary Reviews. RNA·Curtis A Nutter, Muge N Kuyumcu-Martinez
Mar 31, 2018·Frontiers in Molecular Neuroscience·Regina Dahlhaus
Nov 10, 2018·Current Pharmacology Reports·Yijing ZhouYingwei Mao
Mar 14, 2019·Brain Sciences·Rakhi Pal, Aditi Bhattacharya
May 1, 2019·Brain Sciences·Marwa Zafarullah, Flora Tassone
Jun 15, 2019·Cellular and Molecular Life Sciences : CMLS·Venkat Raghavan KrishnaswamyIrit Sagi
May 29, 2020·Molecular Autism·Kagistia Hana UtamiMahmoud A Pouladi
Jul 17, 2020·Frontiers in Cellular Neuroscience·YaLi WangJianGang Wang
Aug 1, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christina GrossGary J Bassell
Dec 12, 2018·Frontiers in Genetics·Inês S AmorimChristos G Gkogkas
Sep 5, 2019·The Journal of Clinical Investigation·Jang Keun KimJeong Ho Lee
Jun 4, 2020·Nature Communications·Xiaoqin ZhanRay W Turner
Apr 25, 2017·Clinical Genetics·A B C DyR Hagerman
❮ Previous
Next ❯
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