Metformin ameliorates olanzapine-induced insulin resistance via suppressing macrophage infiltration and inflammatory responses in rats.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Cuilian GuoHuqun Li

Abstract

The present study aimed to investigate the possible effects of metformin on the olanzapine-induced insulin resistance in rats. Rats were randomly divided into three groups: the control (Control) group, the olanzapine (Ola) group and the olanzapine + metformin (Ola + Met) group. Rats in the Ola group received olanzapine (8 mg/kg/day) intraperitoneally while rats in the Ola + Met group received olanzapine (8 mg/kg/day) intraperitoneally and metformin (300 mg/kg/day) orally for 8 weeks. Rats in the Control group received vehicle accordingly. Body weight and fasting blood glucose were recorded routinely. Inflammatory cytokines TNF-α, IL-6 and IL-1β and IL-10 were measured by ELISA. The gene expression of macrophages markers was examined by qPCR. The epididymal white adipose tissue, liver and skeletal muscle were also isolated for immunohistochemical analysis. Olanzapine significantly induced body weight gain and insulin resistance compared to the control, which was markedly alleviated by metformin. Pro-inflammatory cytokines TNF-α, IL-6 and IL-1β were upregulated while the anti-inflammatory cytokine IL-10 was downregulated by olanzapine in plasma and epididymal white adipose tissue compared to the control, but not the liver and ske...Continue Reading

References

Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Shitij KapurJose N Nobrega
Feb 3, 2005·Nature Medicine·Melek C ArkanMichael Karin
Apr 28, 2005·Diabetes·Steven HaffnerUNKNOWN Diabetes Prevention Program Research Group
Apr 19, 2006·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Trino BaptistaLuis Hernández
Feb 13, 2010·Annual Review of Physiology·Jerrold M Olefsky, Christopher K Glass
Jun 24, 2010·Brain Research·Montserrat VictorianoDominique Hermier
Mar 23, 2011·Journal of Clinical Pharmacy and Therapeutics·Y J Lee, J H Jeong
Aug 21, 2013·Journal of Pharmacology & Pharmacotherapeutics·Rakesh K ChaddaMamta Sood
Mar 29, 2014·PloS One·Yueshan HuGareth E Davies
Jul 30, 2015·European Journal of Immunology·Felix M WensveenBojan Polić
Mar 14, 2017·Cellular Immunology·Ambreen Asghar, Nadeem Sheikh
Jun 2, 2017·Journal of Cellular Biochemistry·Muhammad Sajid Hamid AkashAamira Liaqat
Sep 25, 2017·Molecular and Cellular Endocrinology·Yuanyuan JingRong Li
Dec 5, 2017·Critical Reviews in Eukaryotic Gene Expression·Kanwal RehmanAkhtar Rasul
Sep 20, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jinhui YeYing Ying
Feb 13, 2019·Clinical and Experimental Pharmacology & Physiology·Gönül Kanigur SultuybekGuven Yenmis
Sep 24, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wang ZhangQi-Kui Chen
Jan 22, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Li WangLe-Ping Xu

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Sep 3, 2021·Canadian Journal of Physiology and Pharmacology·Ghada S MahmoudSally A Sayed

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