Metformin and everolimus in neuroendocrine tumours: A synergic effect?

Clinics and Research in Hepatology and Gastroenterology
Lucia Hue-FontaineThomas Walter

Abstract

To explore potential synergy in effectiveness between metformin and everolimus, 2 inhibitors of the mTOR pathway, for neuroendocrine tumours (NET). A cohort of patients with advanced gastroenteropancreatic or lung NETs treated by everolimus were stratified in to those without diabetes, those with diabetes and without metformin, and those with diabetes with metformin. The primary endpoint was the median progression-free survival (PFS). A total of 213 patients were included, 165 of which were non-diabetic; among diabetic patients, 19 were treated with metformin and 29 with others anti-diabetic drugs. No significant difference in median PFS [95%CI] was found between the three groups: 10.05 months [8.27;11.83] for non-diabetic patients, 15.24 [19.88;49.43] for diabetic w/metformin, and 9.03 months [4.01;14.06] for diabetic w/o metformin group. In univariate analysis, factors significantly associated with longer PFS was a functioning NET, a number of metastatic sites<3, the absence of lung metastasis, and an uptake on Octreoscan®, but not the absence of metformin use; only uptake on Octreoscan® remained significant in multivariate analysis. In contrast with the literature, we did not find a synergy between everolimus and metformin i...Continue Reading

References

Jan 14, 2011·Diabetes Care·UNKNOWN American Diabetes Association
Feb 11, 2011·The New England Journal of Medicine·James C YaoUNKNOWN RAD001 in Advanced Neuroendocrine Tumors, Third Trial (RADIANT-3) Study Group
Apr 17, 2012·Cell·Mathieu Laplante, David M Sabatini
May 30, 2015·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Mustafa KinaanChris R Triggle
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisUNKNOWN WHO Panel
Sep 19, 2015·International Journal of Radiation Oncology, Biology, Physics·Marianne Koritzinsky
Dec 26, 2015·Lancet·James C YaoUNKNOWN RAD001 in Advanced Neuroendocrine Tumours, Fourth Trial (RADIANT-4) Study Group
Sep 30, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C CoyleR E Langley
Jun 16, 2017·Investigational New Drugs·Remco J MolenaarJohanna W Wilmink
Aug 5, 2017·Diabetologia·Graham RenaEwan R Pearson
Aug 25, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Guido RindiIan A Cree

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Citations

Jul 15, 2021·Pathology Oncology Research : POR·Anna SebestyénJózsef Tímár
Jul 14, 2021·Molecular Cancer Therapeutics·Gabriel B MpillaAsfar S Azmi

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