Metformin and heart failure-related outcomes in patients with or without diabetes: a systematic review of randomized controlled trials.

Heart Failure Reviews
Phiwayinkosi V DludlaBongani B Nkambule

Abstract

Metformin is considered a safe anti-hyperglycemic drug for patients with type 2 diabetes (T2D); however, information on its impact on heart failure-related outcomes remains inconclusive. The current systematic review explored evidence from randomized clinical trials (RCTs) reporting on the impact of metformin in modulating heart failure-related markers in patients with or without T2D. Electronic databases such as MEDLINE, Cochrane Library, and EMBASE were searched for eligible studies. Included studies were those assessing the use of metformin as an intervention, and also containing the comparison group on placebo, and all articles had to report on measurable heart failure-related indices in individuals with or without T2D. The modified Downs and Black checklist was used to evaluate the risk of bias. Overall, nine studies met the inclusion criteria, enrolling a total of 2486 patients. Although summarized evidence showed that metformin did not affect left ventricular function, this antidiabetic drug could improve myocardial oxygen consumption concomitant to reducing prominent markers of heart failure such as n-terminal pro-brain natriuretic peptide and low-density lipoprotein levels, inconsistently between diabetic and nondiabet...Continue Reading

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Citations

Oct 6, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Phiwayinkosi V DludlaLuca Tiano
Mar 9, 2021·Oxidative Medicine and Cellular Longevity·Shuang Ling, Jin-Wen Xu
Mar 12, 2021·Cardiovascular Research·Shingo TakaharaJason R B Dyck
Apr 28, 2021·Diabetes & Metabolic Syndrome·G GuarinoUNKNOWN Nefrocenter Research Study Group
Mar 31, 2021·Cardiovascular Research·Qutuba G KarwiGary D Lopaschuk
Jul 3, 2021·International Journal of Molecular Sciences·Isabella PanfoliDavide Maggi

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