PMID: 18421184Apr 19, 2008Paper

Metformin and parameters of physical health

Internal Medicine
Mehmet Rami HelvaciAtilla Yalcin

Abstract

The prevalence of excess weight, including overweight and obesity, is increasing with a high cost on health in society. Consecutive cases with excess weight, aged between 50 and 70 years and desiring weight loss, were divided into two subgroups according to wishes of patients about whether they prefer medication or just a diet. Metformin at a daily dose of 2,550 mg was given to the medication group. As for the very high prevalences, 84.8% (313/369) of cases at or above the age of 50 years were overweight or obese, 67.2% (248/369) of them had white coat hypertension (WCH) or hypertension (HT), 52.5% (194/369) of them had impaired glucose tolerance (IGT) or diabetes mellitus (DM), and 68.8% (254/369) of them had dyslipidemia. Initially 143 cases with excess weight preferred the diet and 162 of them preferred the metformin therapy. But 42 cases (25.9%) stopped the drug because of excessive anorexia. At the end of the six-month period, there were highly significant differences between the two groups according to prevalences of resolved WCH, hyperbetalipoproteinemia, hypertriglyceridemia, dyslipidemia, overweight, and obesity and a decreased fasting plasma glucose below 110 mg/dL (p<0.001 for all). Due to the very high prevalences o...Continue Reading

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Citations

Jan 5, 2011·Journal of Obesity·Lorenzo IughettiBarbara Predieri
Aug 30, 2008·International Heart Journal·Mehmet Rami HelvaciAtilla Yalcin
Mar 1, 2009·Expert Review of Endocrinology & Metabolism·Ahmed F Galal, Mohamed F Mitwally
Mar 12, 2020·Frontiers in Cardiovascular Medicine·Alan Chait, Laura J den Hartigh

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