Metformin as an adjuvant in breast cancer treatment

SAGE Open Medicine
Mohsin Hk RoshanNikolai P Pace

Abstract

Breast cancer is one of the most common malignancies in females. It is an etiologically complex disease driven by a multitude of cellular pathways. The proliferation and spread of breast cancer is intimately linked to cellular glucose metabolism, given that glucose is an essential cellular metabolic substrate and that insulin signalling has mitogenic effects. Growing interest has focused on anti-diabetic agents in the management of breast cancer. Epidemiologic studies show that metformin reduces cancer incidence and mortality among type 2 diabetic patients. Preclinical in vitro and in vivo research provides intriguing insight into the cellular mechanisms behind the oncostatic effects of metformin. This article aims to provide an overview of the mechanisms in which metformin may elicit its anti-cancerous effects and discuss its potential role as an adjuvant in the management of breast cancer.

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Citations

Nov 20, 2019·Current Atherosclerosis Reports·Rose Mary Ferreira Lisboa da Silva
Feb 13, 2020·International Journal of Molecular Sciences·Salvador HarguindeyJesús Devesa
May 14, 2020·Analytical Cellular Pathology (Amsterdam)·Chidiebere V UgwuezeBasil C Ezeokpo
Nov 20, 2020·Expert Opinion on Drug Safety·Shahariar Mohammed FahimChiahung Chou
Apr 16, 2021·European Journal of Medicinal Chemistry·Deepika KathuriaPrasad V Bharatam
Aug 17, 2021·Journal of Clinical Pharmacy and Therapeutics·Qiandan WangHongyan Mao
Aug 24, 2021·Frontiers in Pharmacology·He-Ya QianPing-An Zhang

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Methods Mentioned

BETA
xenograft
GTPase
biopsy
nuclear translocation

Clinical Trials Mentioned

NCT00930579
NCT00897884
NCT01589367

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