Metformin effect on gut microbiota: insights for HIV-related inflammation

AIDS Research and Therapy
Jing OuyangJean-Pierre Routy

Abstract

The gut microbiota is emerging as a prominent player in maintaining health through several metabolic and immune pathways. Dysregulation of gut microbiota composition, also known as dysbiosis, is involved in the clinical outcome of diabetes, inflammatory bowel diseases, cancer, aging and HIV infection. Gut dysbiosis and inflammation persist in people living with HIV (PLWH) despite receiving antiretroviral therapy, further contributing to non-AIDS comorbidities. Metformin, a widely used antidiabetic agent, has been found to benefit microbiota composition, promote gut barrier integrity and reduce inflammation in human and animal models of diabetes. Inspired by the effect of metformin on diabetes-related gut dysbiosis, we herein critically review the relevance of metformin to control inflammation in PLWH. Metformin may improve gut microbiota composition, in turn reducing inflammation and risk of non-AIDS comorbidities. This review will pave the way towards innovative strategies to counteract dysregulated microbiota and improve the lives of PLWH.

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Citations

May 25, 2020·The American Journal of Tropical Medicine and Hygiene·Pan LuoJuan Li
Sep 8, 2020·Journal of Zhejiang University. Science. B·Shan-Shan SuoJie Jin
Sep 24, 2020·Open Forum Infectious Diseases·Stéphane IsnardJean-Pierre Routy
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Aug 21, 2020·IScience·Atul MalhotraJohn Y-J Shyy
Dec 15, 2020·Frontiers in Endocrinology·Jing OuyangJean-Pierre Routy
Jan 15, 2021·Viruses·Jerome E Tanner, Caroline Alfieri
Jan 2, 2021·Frontiers in Immunology·Xiaorong PengJean-Pierre Routy
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Clinical Trials Mentioned

NCT03507413
NCT00538486
NCT00343395
NCT00723307
NCT01217307
NCT01879293
NCT03861767
NCT02684578
NCT02325245
NCT01725490

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