Metformin extended release treatment of adolescent obesity: a 48-week randomized, double-blind, placebo-controlled trial with 48-week follow-up.

Archives of Pediatrics & Adolescent Medicine
Darrell M WilsonGlaser Pediatric Research Network Obesity Study Group

Abstract

Metformin has been proffered as a therapy for adolescent obesity, although long-term controlled studies have not been reported. To test the hypothesis that 48 weeks of daily metformin hydrochloride extended release (XR) therapy will reduce body mass index (BMI) in obese adolescents, as compared with placebo. Multicenter, randomized, double-blind, placebo-controlled clinical trial. The 6 centers of the Glaser Pediatric Research Network from October 2003 to August 2007. Obese (BMI > or = 95th percentile) adolescents (aged 13-18 years) were randomly assigned to the intervention (n = 39) or placebo groups. Intervention Following a 1-month run-in period, subjects following a lifestyle intervention program were randomized 1:1 to 48 weeks' treatment with metformin hydrochloride XR, 2000 mg once daily, or an identical placebo. Subjects were monitored for an additional 48 weeks. Main Outcome Measure Change in BMI, adjusted for site, sex, race, ethnicity, and age and metformin vs placebo. After 48 weeks, mean (SE) adjusted BMI increased 0.2 (0.5) in the placebo group and decreased 0.9 (0.5) in the metformin XR group (P = .03). This difference persisted for 12 to 24 weeks after cessation of treatment. No significant effects of metformin o...Continue Reading

Associated Clinical Trials

May 22, 2000·Jack Yanovski, M.D., Jack Yanovski, M.D.

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Citations

Mar 25, 2014·Journal of Endocrinological Investigation·L Pala, C M Rotella
Sep 24, 2013·Journal of the Academy of Nutrition and Dietetics·Deanna M HoelscherUNKNOWN Academy Positions Committee
Feb 15, 2011·Journal of Obesity·Joselyn RojasValmore Bermúdez
Nov 5, 2014·The Annals of Pharmacotherapy·Cassie L BolandKira B Harris
Nov 30, 2016·The Cochrane Database of Systematic Reviews·Emma MeadLouisa J Ells
Oct 6, 2011·Nature Reviews. Gastroenterology & Hepatology·Louise A BaurVanessa A Shrewsbury
Aug 26, 2018·Acta Paediatrica·Elke Wühl
Mar 12, 2013·Current Hypertension Reports·Susan M Halbach, Joseph Flynn
Mar 27, 2013·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·E SergeyevW Kiess

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