Metformin improves endothelial function and carotid intima media thickness in patients with PCOS

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Mehmet G KayaFahrettin Kelestimur

Abstract

Oral contraceptive pills (OCP) are widely used for treating women with polycystic ovary syndrome (PCOS). Metformin has beneficial effects on insulin resistance and endothelial functions. The aim of this study was to investigate the effects of treatment with drospirenone/ethinyl estradiol (EE) alone or in combination with metformin on the flow-mediated vasodilatation (FMD) and carotid intima media thickness (CIMT) in women with PCOS. Fifty women with PCOS (mean age 23 ± 5) were randomized to oral treatment of OCP alone (n = 25) or an OCP combination with metformin (n = 25) for 6 months. FMD from the brachial artery and CIMT were calculated. The hormonal profile, HOMA-IR score, basal insulin and glucose levels were studied in both groups. Before and after 6 months' treatment, echocardiographic measurements and laboratory tests were also obtained. After 6 months' treatment we observed a small decrease in FMD in the OCP group (14.9 ± 9.4 versus 14.4 ± 9.9, p = 0.801) and a slight increase in the combination group (14.5 ± 9.1 versus 15.0 ± 8.0, p = 0.715) but neither of them reached significance. CIMT increased in the OCP group (0.048 ± 0.011 to 0.050 ± 0.010 cm, p = 0.433) and decreased slightly in the combination group (0.049 ± 0....Continue Reading

References

Jun 12, 2002·Fertility and Sterility·Fernando Ovalle, Ricardo Azziz
Dec 25, 2003·Diabetes Care·UNKNOWN American Diabetes Association
Mar 25, 2005·The New England Journal of Medicine·David A Ehrmann
Mar 28, 2006·The American Journal of Medicine·E CarminaRogerio A Lobo
Aug 31, 2006·The Journal of Clinical Endocrinology and Metabolism·Teresa CascellaFrancesco Orio
Aug 28, 2007·Lancet·Robert J NormanTheresa E Hickey
Oct 28, 2008·Fertility and Sterility·Ricardo AzzizUNKNOWN Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society
May 25, 2010·Fertility and Sterility·Mehmet Gungor KayaFahrettin Kelestimur
Jun 16, 2010·Echocardiography·Mehmet Tugrul InancAbdurrahman Oguzhan
Jul 16, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-François ArnalPierre Gourdy
Nov 4, 2011·Trends in Endocrinology and Metabolism : TEM·Trang N LeEdmond P Wickham
Feb 1, 2013·Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır·Selen YurdakulSaide Aytekin

❮ Previous
Next ❯

Citations

Jan 22, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Neja MudrovcicKarolina Kublickiene
Aug 15, 2020·The Cochrane Database of Systematic Reviews·Eloise FraisonMichael F Costello
Jul 17, 2020·Therapeutic Advances in Endocrinology and Metabolism·Mohammed Altigani AbdallaThozhukat Sathyapalan
May 2, 2017·Climacteric : the Journal of the International Menopause Society·M N Gunning, B C J M Fauser
Dec 12, 2020·Expert Review of Clinical Pharmacology·Xiao ChenDongdong Wang
Aug 29, 2021·Heart, Lung & Circulation·Ute SeelandUNKNOWN Sex and Gender VascAgeNet Expert Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.