Metformin-Induced Changes of the Coding Transcriptome and Non-Coding RNAs in the Livers of Non-Alcoholic Fatty Liver Disease Mice

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Jun GuoJian Li

Abstract

Recent studies have suggested that changes in non-coding mRNA play a key role in the progression of non-alcoholic fatty liver disease (NAFLD). Metformin is now recommended and effective for the treatment of NAFLD. We hope the current analyses of the non-coding mRNA transcriptome will provide a better presentation of the potential roles of mRNAs and long non-coding RNAs (lncRNAs) that underlie NAFLD and metformin intervention. The present study mainly analysed changes in the coding transcriptome and non-coding RNAs after the application of a five-week metformin intervention. Liver samples from three groups of mice were harvested for transcriptome profiling, which covered mRNA, lncRNA, microRNA (miRNA) and circular RNA (circRNA), using a microarray technique. A systematic alleviation of high-fat diet (HFD)-induced transcriptome alterations by metformin was observed. The metformin treatment largely reversed the correlations with diabetes-related pathways. Our analysis also suggested interaction networks between differentially expressed lncRNAs and known hepatic disease genes and interactions between circRNA and their disease-related miRNA partners. Eight HFD-responsive lncRNAs and three metformin-responsive lncRNAs were noted due ...Continue Reading

Citations

Nov 18, 2018·The Journal of Rheumatology·Jung Sun LeeSeokchan Hong
Sep 17, 2019·International Journal of Molecular Medicine·Yanhong YangJiao Guo
Mar 11, 2020·International Journal of Molecular Sciences·Xiaodong TanJie Wen
Dec 7, 2019·Journal of the Chinese Medical Association : JCMA·Yueh ChienChien-Ying Wang
Jul 3, 2021·International Journal of Molecular Sciences·Marwa MatboliSanaa Eissa
Aug 28, 2021·Cells·Xianhui ZengJinhang Gao

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