Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells

Leukemia
Ameet K Mishra, David Dingli

Abstract

IL-6 signaling plays a crucial role in the pathogenesis of a number of diseases, including multiple myeloma, primary amyloidosis, cytokine release syndrome and other inflammatory conditions. It is central for the growth and survival of malignant plasma cells. IL-6R and IL-6ST receptors transduce IL-6 signaling. Molecular mechanisms regulating expression of IL-6R are not well understood and current therapies are based on monoclonal antibody to target IL-6 signaling. Small molecule inhibitors targeting IL-6 signaling are highly desirable. Metformin specifically decreased IL-6R expression which is mediated via AMPK, mTOR, and miR34a. This is a novel finding and adds to existing therapies targeting IL-6 signaling.

References

Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T HiranoT Kishimoto
Jan 1, 1989·International Archives of Allergy and Applied Immunology·T HiranoH Yawata
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K M KozopasR W Craig
Oct 17, 1998·Diabetes Care·J B BrownP Latare
Dec 3, 1999·British Journal of Haematology·D PuthierM Amiot
Jan 8, 2000·Hematology/oncology Clinics of North America·D F Jelinek
May 30, 2003·The Biochemical Journal·Peter C HeinrichFred Schaper
Sep 25, 2003·Science's STKE : Signal Transduction Knowledge Environment·Gerhard Müller-Newen
Mar 18, 2005·Annual Review of Immunology·Tadamitsu Kishimoto
Oct 26, 2006·Cancer Research·Mahvash ZakikhaniMichael Pollak
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Molly M McFarland-ManciniAngela F Drew
Aug 13, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jean-Daniel Lalau
Oct 25, 2011·Annual Review of Pharmacology and Toxicology·Ken InokiKun-Liang Guan
Mar 23, 2012·Nature Reviews. Molecular Cell Biology·D Grahame HardieSimon A Hawley
Nov 9, 2012·International Journal of Biological Sciences·Stefan Rose-John
Feb 19, 2013·Diabetology & Metabolic Syndrome·Lilian Beatriz Aguayo Rojas, Marilia Brito Gomes
Mar 20, 2014·The Journal of Clinical Investigation·Matjaz RokavecHeiko Hermeking
May 21, 2014·ELife·William W WheatonNavdeep S Chandel
Jul 6, 2014·International Journal of Molecular Medicine·Jan SommerJürgen Scheller
Aug 20, 2014·Nature Reviews. Rheumatology·Leonard H Calabrese, Stefan Rose-John
Sep 6, 2014·Cold Spring Harbor Perspectives in Biology·Toshio TanakaTadamitsu Kishimoto
Nov 12, 2014·Annual Review of Medicine·Daniel R Morales, Andrew D Morris
Nov 21, 2014·Science Translational Medicine·Amit SinghalGennaro De Libero
Aug 5, 2017·Diabetologia·Clifford J Bailey
May 9, 2018·PloS One·Abdellatif AharazAnnmarie Touborg Lassen

❮ Previous
Next ❯

Citations

Apr 15, 2020·Journal of Toxicology and Environmental Health. Part a·Weixin WangKatherine R Calvo
Jul 28, 2019·Archives of Gynecology and Obstetrics·Raffaella Mormile
Oct 21, 2020·Biomolecules & Therapeutics·Dong Wook Shin
Jan 23, 2021·The Journal of International Medical Research·Feifei YangYanli Xu
Jan 9, 2021·Blood Cancer Journal·Ameet K MishraDavid Dingli
Nov 17, 2020·Frontiers in Public Health·Veronica C JonesVictoria L Seewaldt
Nov 27, 2020·Drug Design, Development and Therapy·Nicholas BorcherdingPraveen Vikas
Mar 16, 2021·Frontiers in Immunology·Samuel S McCachrenMadhav V Dhodapkar
Feb 14, 2021·Journal of Medical Virology·Carolyn T BramanteChristopher J Tignanelli
Mar 23, 2021·Oncology Reviews·Monika Podhorecka

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE36133

Methods Mentioned

BETA
ELISA
PCR
flow cytometry
transfection
RNAseq

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Related Papers

Journal of the Royal Society of Medicine
D R NairA F Winder
American Practitioner and Digest of Treatment
Ryōikibetsu shōkōgun shirīzu
K Hirota, S Furusawa
© 2021 Meta ULC. All rights reserved