Metformin initiation and renal impairment: a cohort study in Denmark and the UK

BMJ Open
Christian Fynbo ChristiansenSusan Jick

Abstract

To estimate prevalence of renal impairment, rate of decline in kidney function and changes in metformin use after decline in kidney function, in metformin initiators. We conducted this 2-country cohort study using routine data from northern Denmark and the UK during 2000-2011. We included metformin initiators among patients aged ≥30 years with medically treated diabetes. We described patients' demographics, comorbidity, co-medications and their estimated glomerular filtration rates (eGFR). Furthermore, we described the patients' characteristics according to eGFR level. Finally, we examined the rate of any decline in eGFR and changes in metformin use within 90 days after first decline in eGFR during follow-up. We included 124,720 metformin initiators in the 2 countries. Prevalence of eGFR <60 mL/min/1.73 m(2) among metformin initiators was 9.0% in Denmark and 25.2% in the UK. In contrast, prevalence of eGFR values <30 mL/min/1.73 m(2) among metformin initiators was 0.3% in Denmark and 0.4% in the UK. Patients with renal impairment were older and more likely to have received cardiovascular drugs. Incidence rate of decline in renal function was 4.92 per 100 person-years (95% CI 4.76 to 5.09) in Denmark and 7.48 per 100 person-year...Continue Reading

References

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Citations

Aug 10, 2016·Diabetic Medicine : a Journal of the British Diabetic Association·L LiV Ehrenstein
Nov 23, 2018·Journal of Endocrinological Investigation·G ErminiUNKNOWN Bologna Section of the Italian College of General Practitioners and Primary Care
Dec 17, 2020·International Journal of General Medicine·Mohamed Hassan ElnaemEjaz Cheema
Jul 3, 2021·Journal of Clinical Medicine·Clara García-CarroMaría José Soler

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