Metformin Is Associated With Slightly Reduced Risk of Colorectal Cancer and Moderate Survival Benefits in Diabetes Mellitus: A Meta-Analysis

Medicine
Xing-Kang HeLei-min Sun

Abstract

To systematically assess the effect of metformin on colorectal cancer (CRC) risk and mortality in type 2 diabetes mellitus (T2DM) patients. We conducted a systematic search of PubMed, Web of Science, and the Cochrane Library databases for relevant articles before August 2015. Two investigators identified and extracted data independently. We adopted adjusted estimates to calculate summary estimates with 95% confidence interval (CI) using either a fixed-effects or a random-effects model. Subgroup and sensitivity analyses were conducted to evaluate the robustness of the pooled results. The risk of publication bias was assessed by examining funnel plot asymmetry as well as Begg test and Egger test. Fifteen studies on CRC incidence and 6 studies on CRC survival were finally included in our meta-analysis. The pooled odds ratio (OR) of observational studies illustrated that a slight 10% reduction of CRC incidence was associated with metformin use (OR = 0.90, 95% CI: 0.85-0.96). Furthermore, the pooled hazard ratio (HR) revealed an improved survival outcome for metformin users in CRC patients compared to nonusers (HR = 0.68, 95% CI: 0.58-081). There was no publication bias across studies. Our meta-analysis demonstrated that metformin t...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Nov 19, 1994·BMJ : British Medical Journal·S G Thompson
Oct 17, 2001·The Journal of Clinical Investigation·G ZhouD E Moller
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Feb 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey A MeyerhardtCharles S Fuchs
Oct 14, 2004·Gastroenterology·Yu-Xiao YangJames D Lewis
Sep 23, 2008·Cancer Science·Ayako TomimotoAtsushi Nakajima
Dec 2, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C La VecchiaF Levi
Jul 1, 2010·Diabetes Care·Edward GiovannucciDouglas Yee
Oct 16, 2010·Cancer Prevention Research·Andrea DecensiSara Gandini
Oct 16, 2010·Cancer Biology & Therapy·Jennifer WoodardLeonidas C Platanias
Dec 15, 2010·The Oncologist·Heinz-Josef KlümpenJan H M Schellens
Mar 31, 2011·Diabetes Care·Assiamira FerraraLaurel A Habel
Jun 3, 2011·Journal of Diabetes·Donghui Li
Jul 26, 2011·BMJ : British Medical Journal·Jonathan A C SterneJulian P T Higgins
Sep 14, 2011·International Journal of Cancer. Journal International Du Cancer·Jin Ha LeeWon Ho Kim
Dec 20, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Michael BodmerChristoph R Meier
Dec 29, 2011·Oncotarget·Sonia Del BarcoJavier A Menendez
Jul 11, 2012·European Journal of Endocrinology·Chin-Hsiao Tseng
Nov 23, 2012·Diabetes Care·Samy Suissa, Laurent Azoulay
Jun 12, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Susan SpillaneThomas I Barron
Jun 19, 2013·Cancer Epidemiology·Furha Iram CossorJessica K Paulus
Aug 24, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Brielan SmiechowskiSamy Suissa
Sep 18, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Siddharth SinghPaul J Limburg
Nov 13, 2013·Current Drug Safety·Lotte M KnapenMarloes T Bazelier
Mar 4, 2014·Endocrinology and Metabolism Clinics of North America·Zara Zelenko, Emily Jane Gallagher
Jun 4, 2014·CA: a Cancer Journal for Clinicians·Carol E DeSantisAhmedin Jemal
Jul 24, 2014·Journal of the American Medical Informatics Association : JAMIA·Hua XuJoshua C Denny

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Citations

Apr 28, 2017·Journal of Gastroenterology and Hepatology·Yoon Suk JungDong Soo Han
Dec 5, 2017·Indian Journal of Cancer·S ZhongJ Zhao
Sep 16, 2018·Journal of Clinical Pharmacy and Therapeutics·Rashmi R Shah, Peter D Stonier
Jan 10, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Jing-Hong YeLu Ye
Dec 27, 2016·World Journal of Gastroenterology : WJG·Patrizia FerroniMario Roselli
Aug 5, 2017·Diabetologia·Brandy M Heckman-StoddardLeslie G Ford
Dec 23, 2017·Biological Chemistry·Stephen SafeKeshav Karki
Oct 18, 2019·Frontiers in Endocrinology·Hong YuYongxi Song
Feb 16, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y ShuaiX Zhou
Nov 15, 2019·Clinical and Translational Gastroenterology·Joshua DembSamir Gupta
Nov 21, 2017·Chinese Journal of Cancer·UNKNOWN Editorial Office of Chinese Journal of Cancer
Mar 9, 2017·Journal of Diabetes Research·Fanqiang MengWenyue Wang
Aug 9, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jessica K PaulusRobert E Martell
Nov 27, 2019·Clinical and Translational Gastroenterology·Joshua DembSamir Gupta
May 20, 2021·World Journal of Gastroenterology : WJG·Ademar Dantas Cunha JúniorJosé Barreto Campello Carvalheira
Feb 20, 2021·International Journal of Clinical Endocrinology and Metabolism·Gil HevroniSamy I McFarlane
Jul 24, 2020·Clinical Diabetes : a Publication of the American Diabetes Association·Pranay R Bonagiri, Jay H Shubrook
Jan 14, 2022·Digestive Diseases and Sciences·Anna KrigelJames L Araujo

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